Table 1: Published clinical experiences of cell treatments of anal fistula (Part 1). An update of the tables taken from the section “Stem Cell Application in Fistula Disease” [33].

Investigators	Year of publication	Trial code	Location	Condition	Study design	Cell source	Expanded	Cells number
García-Olmo et al. [34]	2003	NA	Spain	Recto-vaginal fistula in Crohn’s disease	Case report	Autologous fat	Yes	1 × 10e7
García-Olmo et al. [41]	2005	Not registered	Spain	Enterocutaneous, recto-vaginal, perianal fistula in Crohn’s disease	Phase I	Autologous fat	Yes	1-3 × 10e7 resuspended in fibrin glue
García-Olmo et al. [25]	2009	NCT00115466	Spain	Perianal fistula with or without Crohn’s disease	Phase II	Autologous fat	Yes	Not specified
García-Olmo et al. [40]	2010	NA	Spain	Recto-vaginal fistula in Crohn’s disease	Case report	Allogeneic fat	Yes	Not specified
Ciccocioppo et al. [39]	2011	NA	Italy	Enterocutaneous, complex perianal fistula in Crohn’s disease	Case report	Autologous bone marrow	Yes	5 × 10e7
Herreros et al. [27]	2012	NCT00475410	Spain	Complex perianal fistula without Crohn’s disease	Phase III	Autologous fat	Yes	2 × 10e7 then 4 × 10e7 when no effect
Herreros et al. [27]	2012	NCT01020825	Spain	Perianal fistula with or without Crohn’s disease	Observational	Autologous fat	Yes	2 × 10e7 then 4 × 10e7 when no effect
Guadalajara et al. [42]	2012	Not registered	Spain	Perianal fistula with or without Crohn’s disease	Observational	Autologous fat	Yes	Not specified
Borowski et al. [35]	2012	NA	UK	Perianal fistula without Crohn’s disease	Case report	Autologous fat	No	Not specified
de la Portilla et al. [37]	2013	NCT01372969	Spain	Perianal fistula in Crohn’s disease	Phase I/II	Allogeneic fat	Yes	2 × 10e7 then 4 × 10e7 when no effect
Cho et al. [38]	2013	NCT00992485	Korea	Complex perianal fistula in Crohn’s disease	Phase I	Autologous fat	Yes	1 × 10e7, 2 × 10e7, 4 × 10e7
Lee et al. [36]	2013	NCT01011244	Korea	Complex perianal fistula in Crohn’s disease	Phase II	Autologous fat	Yes	3 × 10e7 per cm length of the fistula. Initial dose × 1.5 when no effect
Cho et al. [43]	2015	NCT01011244 long term	Korea	Complex perianal fistula in Crohn’s disease	Phase II	Autologous fat	Yes	3 × 10e7 per cm length of the fistula. Initial dose × 1.5 when no effect
Ciccocioppo et al. [44]	2015	NA	Italy	Enterocutaneous, complex perianal fistula in Crohn’s disease	Case report	Autologous bone marrow	Yes	5 × 10e7
García-Olmo et al. [45]	2015	NA	Spain	Complex perianal fistula with or without Crohn’s disease	Case report	Autologous fat	Both	Not specified
Molendijk et al. [24]	2015	NCT01144962	Netherlands	Perianal fistula in Crohn's disease	Phase I/II	Allogeneic bone marrow	Yes	1 × 10e7, 3 × 10e7, 9 × 10e7
Borowski et al. [46]	2015	NA	UK	Perianal fistula without Crohn’s disease	Case report	Autologous fat	No	Not specified
Park KJ. [47]	2015	NCT01440699	Korea	Perianal fistula in Crohn's disease	Phase I	Allogeneic fat	Yes	1 × 10e7, 3 × 10e7