Table 4: Ongoing clinical trials using cells for treatment of anal fistula (Part 2). An update of the tables taken from the section “Stem Cell Application in Fistula Disease”. [33] ASCs: adult stem cells. Source: Clinicaltrials.gov

Trial code	Cell Source	Expanded	Cells number	Status	Phase	Intervention model	Masking	Estimated enrollment
NCT00999115	Allogeneic fat	Yes	2 ×10e7, when no effect   4 ×10e7	Completed. Publications not provided	1.2	Single arm	Open label	10
NCT01541579	Allogeneic fat	Yes	12 × 10e7	Ongoing, not recruiting	3	Two arms: (ASCs, placebo)	Double blind	208
NCT00482092	Allogeneic bone marrow	Yes	120 × 10e7 or 60 × 10e7 cells infused in four visits	Ongoing, not recruiting	3	Three arms: Placebo, high dose and low dose	Double blind	270
NCT01803347	Autologous fat	Yes	10 × 10e7, additional dose when no effect	Recruiting	3	Two arms: ASCs + fibrin glue, fibrin glue	Double blind	80
NCT02403232	Autologous fat	No	Not specified	Recruiting	2	Single arm ASCs + infliximab	Open label	10
NCT01915927	Autologous fat	Yes	2 × 10e7	Recruiting	1	Stem-cell-coated plug	Open label	20
NCT01874015	Autologous bone marrow	Yes	Dose not specified. 4 injections	Recruiting	1	Two arms: ASCs + fibrin, ASCs + fibroblast + fibrin	Single blind	10
NCT02000362	Allogeneic umbilical cord	Yes	5 × 10e7 or 1 × 10e8	Recruiting	1.2	Two arms: low dose, high dose	Open label	24
NCT02520843	Autologous fat	No	Not specified	Recruiting	1.2	Single arm	Open label	10
NCT02677350	Allogeneic bone marrow	Yes	2 × 10e7 divided in 10 inyections of 2 millon	Recruiting	1	Single arm	Open label	20