Table 1: Mechanism of action, interactions and adverse reactions of the interventions included in this systematic review.

Baseline total - 2,586 patients

1. 1 month - 1,643; Improve - 1,150 (69.99%); Not improve - 408

2. 3 month - 1,330; Improve - 1,027 (77%); Not improve - 226

3. 6 month - 1,097; Improve - 862 (78.58%); Not improve - 154

4. 9 month - 803; Improve - 642 (79.95%); Not improve - 96

5. 1 year - 615; Improve - 495; (80.49%); Not improve - 69

6. 1 year 3 months - 363; Improve 293 (80.72%); Not improve - 34

7. 1 year 6 months - 248; Improve - 198 (79.84%); Not improve - 25

8. 2 years - 212; Improve - 165 (77.83%); Not improve - 23

9. 3 years - 57; Improve - 47 (82.46%); Not improve - 7

10. 4 years - 15; Improve - 13 (86.67%); Not improve - 1

11. 5 years - 4; Improve - 4 (100%); Not improve - 0