Basic criteria (Required)

Fever^* (Required)

Primary clinical criteria^* (Need at least one)

Secondary clinical criteria^* (Need at least two if only one primary criteria met)

Laboratory evidence (Both 1 and 2 required)

Age ≥ 21 years

Hospitalized for ≥ 24 hours, or with an illness resulting in death.

Subjective fever or documented fever (≥ 38.0 °C).

1. Severe cardiac illness Includes myocarditis, pericarditis, coronary artery dilatation/aneurysm, or new- onset right or left ventricular dysfunction (LVEF < 50%), 2^nd/3^rd degree A-V block, or ventricular tachycardia. (Note: cardiac arrest alone does not meet this criterion).

2. Rash AND non-purulent conjunctivitis.

1. New-onset neurologic signs and symptoms Includes encephalopathy in a patient without prior cognitive impairment, seizures, meningeal signs, or peripheral neuropathy (including Guillain-Barré syndrome).

2. Shock or hypotension not attributable to medical therapy (e.g., sedation, renal replacement therapy).

3. Abdominal pain, vomiting, or diarrhea.

4. Thrombocytopenia (platelet count < 150,000/ microliter).

1. Elevated levels of at least TWO of the following: C-reactive protein, ferritin, IL-6, erythrocyte sedimentation rate, procalcitonin.

2. A positive SARS-CoV-2 test for current or recent infection by RT-PCR, serology, or antigen detection.