Table 3: Diagnostic indices and how nested PCR agreed with Bu-LAMP and conventional PCR.
|
Indices |
BU-LAMP |
Conventional PCR |
|
True positive |
119 |
104 |
|
True negative |
19 |
19 |
|
False positive |
0 |
0 |
|
False negative |
3 |
19 |
|
Sensitivity (95% CI) |
97.5% (92.9-99.5%) |
84.6% (76.9-90.4%) |
|
Specificity (95% CI) |
100.0 (82.35-100.0) |
100.0 (82.35-100.0) |
|
PPV (95% CI) |
100.0 |
100.0 |
|
NPV (95% CI) |
86.4% (67.4-95.1%) |
50.00% (39.81-60.19%) |
|
Kappa value |
0.88% (0.564-0.741) |
0.59% (0.51-0.69) |
|
% agreement |
97.16 |
86.62 |
Values in parenthesis is 95% confidence interval.