Table 2: Antileishmanial activity and cytotoxicity of aryl-substituted imidazoles.

Compounds

L. infantum [1]

IC50 ± SD (μM)

L. amazonensis

IC50 ± SD (μM)

BALB/c mice

Macrophages

CC50 ± SD (μM)

SI

1

1.02 ± 0.02

6.98 ± 0.8

178.09 ± 3.5

26

2

> 64.0

8.94 ± 1.0

69.32 ± 1.5

8

3

-

16.22 ± 0.3

126.07 ± 5.2

8

4

10.23 ± 1.16

10.35 ± 1.2

178.27 ± 0.9

17

5

4.11 ± 0.51

15.94 ± 2.4

11.90 ± 0.8

1

6

1.99 ± 0.19

> 46.35

41.48 ± 0.5

1

7

40.89 ± 6.21

6.72 ± 0.6

41.48 ± 0.6

6

8

16.44 ± 1.77

26.27 ± 0.7

30.77 ± 0.8

1

9

4.07 ± 0.42

31.52 ± 0.2

25.63 ± 0.4

1

Ref. drug

10.07 ± 4.23

0.03 ± 0.006

6.16 ± 0.5

193

IC50: concentration of compound that caused 50% of inhibition growth; SD: Standard Deviation.

Ref. drug: Miltefosine for L. infantum; Amphotericin B for L. amazonensis [15].