compounds

2JK6

1T5F

3NGU^*

Leishmania infantum

(Trypanothione Reductase)

Rattus norvegicus

(Arginase I)

Leishmania major

(NDKb)

ΔG (kcal/mol)

Ki (nM)

ΔG (kcal/mol)

Ki (nM)

ΔG (kcal/mol)

Ki (nM)

1

-10.06

42.45

-8.68

433.09

-10.33

26.82

2

-10.1

39.77

-9.55

99.7

-9.57

97.18

3

-10.53

19.20

-10.28

29.14

-10.12

38.43

4

-10.32

27.37

-9.33

143.84

-9.67

81.25

5

-9.81

63.93

-7.2

5.24^*

-9.23

172.09

6

-9.36

136.91

-8.7

417.14

-9.24

169.05

7

-9.25

165.99

-8.96

269.45

-8.98

262.16

8

-10.86

11.00

-8.98

260.08

-7.99

1.40^*

9

-9.33

144.90

-7.04

6.96^*

-9.27

160.23

Std-TryR

-11.30

5.19

Std-ArgI

-6.32

23.38^*

Std-NDKb

-9.03

238.87