Table 1: Detection of mercury ions, Hg2+ using optical-based or electrochemical-based biosensor.

Sensor type Capturing agents LOD (ppb) Detection time Practical for in-situ analysis References
Optical-based biosensor AunPs with 3-mercaptopropionic acid and adenosine monophosphate 100 Several minutes Yes Yu and Tseng [93]
Papain-functionalized gold-nanoparticles (P-AuNPs) 40 Several minutes Yes Guo, et al. [95]
Cysteine functionalized gold- nanoparticles (C-AunPs) 20 > 10 minutes Yes Chai, et al. [102]
AuNPs modified with quaternary ammonium group-terminated thiols 6 Several minutes No Liu, et al. [99]
Mercaptopropionic acid-homocysteine-PDCA-modified gold nanoparticles 5 15 minutes Yes Darbha, et al. [103]
Aggregation-induced quenching of the fluorescence of 11-mercaptoundecanoic acid (11-MUA) protected 20 nm AuNPs 1 10 minutes No Huang, et al. [86]
Electrochemical-based sensor Heated carbon nanoparticles 1 2 minutes No Aragay, et al. [78]
Protein-functionalized reduced graphene oxide (rGO) 0.2 Few seconds No Sudibya, et al. [104]
Bimetallic Au-Pt nanoparticles/organic nanofibers with anodic stripping voltammetry 0.08 100 seconds No Gong, et al. [105]
AuNPs-graphene hybrid nanocomposite 0.06 110 seconds No Gong, et al. [106]
Gold nanoparticles/carbon nanotubes (Au-NPs/CNTs) composites with anodic stripping voltammetry 0.06 2 minutes No Xu, et al. [107]
Nanostructured magnesium silicate hollow spheres 0.07 Several minutes No Xu, et al. [108]
Electrochemically reduced GO (ERGO)-based diode with N-[(1-pyrenyl-sulfonamido)-heptyl]-gluconamide (PG) as the modifier 0.02 Several minutes No Fang & Liu [109]
Layered titanate nanosheets 0.005 80 seconds No Yuan, et al. [110]