Table 4: Effect of chlorpyrifos(1/10 LD50, 33.3 mg kg-1 body weight) on serum glucose and bilirubin levels in male domestic rabbits.
Parameter |
Treatment |
Experimental period (weeks) |
|||||
1 |
2 |
3 |
4 |
5 |
6 |
||
Glucose (mg/dl) |
Control |
114.3 ± 2.8 |
117.2 ± 3.6 |
113.0 ± 3.9 |
118.1 ± 4.0 |
114.0 ± 3.5 |
115.6 ± 4.2 |
Chlorpyrifos |
110.6 ± 3.0 |
129.7 ± 3.8 |
148.6 ± 4.9 |
142.0 ± 4.7 |
141.5 ± 4.8 |
138.2 ± 4.6 |
|
p-value |
0.392 |
0.071 |
0.002 |
0.013 |
0.010 |
0.022 |
|
Bilirubin (mg/dl) |
Control |
1.64 ± 0.04 |
1.70 ± 0.05 |
1.71 ± 0.04 |
1.69 ± 0.02 |
1.64 ± 0.03 |
1.72 ± 0.06 |
Chlorpyrifos |
1.70 ± 0.06 |
1.79 ± 0.07 |
1.85 ± 0.09 |
1.88 ± 0.11 |
1.91 ± 0.10 |
1.94 ± 0.08 |
|
p-value |
0.439 |
0.320 |
0.195 |
0.097 |
0.044 |
0.081 |
The number of animals was 6 per time interval for each control and chlorpyrifos-treated rabbits. All values are expressed as mean ± SEM. p < 0.05: significant.