Effect of chlorpyrifos (1/10 LD50, 33.3 mg kg-1 body weight) on serum ALT, AST, γ-GT, ALP, and ChE activities in male domestic rabbits.

Table 5: Effect of chlorpyrifos (1/10 LD50, 33.3 mg kg-1 body weight) on serum ALT, AST, γ-GT, ALP, and ChE activities in male domestic rabbits.

Parameter	Treatment	Experimental period (weeks)
Parameter	Treatment	1	2	3	4	5	6
ALT (U/L)	Control	49.5 ± 1.7	48.7 ± 2.4	49.1 ± 1.6	49.5 ± 1.7	51.2 ± 2.3	51.0 ± 2.5
	Chlorpyrifos	55.3 ± 1.8	54.1 ± 1.9	57.5 ± 2.3	66.3 ± 2.8	69.4 ± 2.7	64.5 ± 2.6
	p -value	0.055	0.131	0.026	0.003	0.007	0.020
AST (U/L)	Control	34.2 ± 1.6	32.8 ± 1.5	33.6 ± 1.4	34.0 ± 2.0	33.5 ± 1.7	33.1 ± 1.8
	Chlorpyrifos	41.3 ± 2.3	44.1 ± 2.2	48.9 ± 2.7	43.8 ± 2.2	42.5 ± 2.4	40.7 ± 2.1
	p -value	0.046	0.006	0.003	0.029	0.037	0.040
ˠ-GT (U/L)	Control	6.0 ± 0.28	5.8 ± 0.25	5.7 ± 0.27	5.9 ± 0.25	6.1 ± 0.24	5.8 ± 0.21
	Chlorpyrifos	6.9 ± 0.31	6.9 ± 0.33	7.0 ± 0.35	7.6 ± 0.37	7.6 ± 0.36	7.8 ± 0.35
	p -value	0.073	0.037	0.026	0.010	0.023	0.008
ALP (U/L)	Control	98.3 ± 3.2	97.6 ± 2.8	103.1 ± 4.0	96.9 ± 2.5	98.7 ± 3.0	100.2 ± 2.9
	Chlorpyrifos	96.8 ± 3.7	91.7 ± 1.9	112.4 ± 4.1	126.9 ± 4.5	123.2 ± 4.3	122.1 ± 3.8
	p -value	0.787	0.135	0.178	0.002	0.005	0.011
ChE (U/L)	Control	4540 ± 156	4603 ± 142	4782 ± 150	4519 ± 128	4811 ± 149	4647 ± 141
	Chlorpyrifos	2623 ± 91	2514 ± 102	2536 ± 85	2312 ± 79	2590 ± 103	2605 ± 101
	p-value	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001

ALT: Alanine Aminotransferase; AST: Aspartate Aminotransferase; γ-GT: Gamma-Glutamyltransferase; ALP: Alkaline Phosphatase; ChE: cholinesterase.
The number of animals was 6 per time interval for each control and chlorpyrifos-treated rabbits. All values are expressed as mean ± SEM. p < 0.05: significant.