Table 7: Effect of chlorpyrifos(1/10 LD50, 33.3 mg kg-1 body weight) on serum total protein, albumin and globulin levels in male domestic rabbits.
|
Parameter |
Treatment |
Experimental period (weeks) |
|||||
|
1 |
2 |
3 |
4 |
5 |
6 |
||
|
Total protein (mg/dl) |
Control |
6.1 ± 0.28 |
5.8 ± 0.23 |
5.7 ± 0.19 |
6.2 ± 0.25 |
6.0 ± 0.26 |
5.9 ± 0.21 |
|
Chlorpyrifos |
5.6 ± 0.21 |
5.0 ± 0.19 |
4.7 ± 0.22 |
4.8 ± 0.20 |
4.9 ± 0.18 |
4.7 ± 0.20 |
|
|
p-value |
0.221 |
0.060 |
0.029 |
0.013 |
0.025 |
0.015 |
|
|
Albumin (mg/dl) |
Control |
3.58 ± 0.11 |
3.73 ± 0.13 |
4.00 ± 0.20 |
3.66 ± 0.17 |
3.78 ± 0.15 |
3.95 ± 0.19 |
|
Chlorpyrifos |
3.27 ± 0.14 |
3.29 ± 0.12 |
3.21 ± 0.10 |
3.05 ± 0.08 |
3.07 ± 0.07 |
3.00 ± 0.08 |
|
|
p-value |
0.141 |
0.047 |
0.012 |
0.036 |
0.014 |
0.010 |
|
|
Globulin (mg/dl) |
Control |
2.30 ± 0.11 |
2.05 ± 0.09 |
1.97 ± 0.10 |
2.31 ± 0.13 |
2.16 ± 0.12 |
1.94 ± 0.10 |
|
Chlorpyrifos |
2.16 ± 0.09 |
1.82 ± 0.07 |
1.61 ± 0.06 |
1.81 ± 0.08 |
1.74 ± 0.05 |
1.46 ± 0.03 |
|
|
p-value |
0.388 |
0.109 |
0.032 |
0.027 |
0.030 |
0.009 |
|
The number of animals was 6 per time interval for each control and chlorpyrifos-treated rabbits. All values are expressed as mean ± SEM. p < 0.05: significant.