Table 5: Pathological incidence in male Sprague-Dawley rats after repeated iv injections of DINP and other test materials for 4 wk.
| Pathological change type | Pathological incidence (n/n) | ||||
| Control | 125 mg/kg DINP | 250 mg/kg DINP | 500 mg/kg DINP | 500 mg/kg DEHP | |
| Tiny hepatic granulomas | 0/10 | 0/10 | 0/10 | 2/10 | 2/10 |
| Liver header lymphocyte infiltration | 0/10 | 0/10 | 0/10 | 3/10 | 4/9 |
| Liver vacuolation | 0/10 | 0/10 | 0/10 | 0/10 | 4/9 |
| Small local hepatic necrosis | 0/10 | 0/10 | 0/10 | 1/10 | 4/9 |
| Regional lymphocytes infiltration in kidney | 1/10 | 1/10 | 1/10 | 1/10 | 4/9 |
| Small local nephritic necrosis | 0/10 | 0/10 | 0/10 | 0/10 | 4/9 |
| Testis local seminiferous tubule epithelium spermatocyte and spermatid disappearance | 0/10 | 0/10 | 0/10 | 1/10 | 4/9 |