Table 2: Donor, procedural and recipient risk factors
for primary graft dysfunction.
Preservation
Solution |
STS
(n = 100) |
Celsior
(n = 104) |
Celsior+EPO+GTN
(n = 61) |
p-value |
DONOR
FACTORS |
|
|
|
|
Donor
age (years, mean ± SD) |
33 ± 13 |
37 ± 14 |
38 ± 13 |
ns |
Donor
weight (kg, mean ± SD) |
79 ± 14 |
78 ± 15 |
81 ± 15 |
ns |
Cause
of death (n, %) Head
trauma CVA
or ICH Cardiac
arrest OtherŘ |
36 (36%) 55 (55%) 1 (1%) 8 (8%) |
29 (28%) 53 (51%) 2 (2%) 20 (19%) |
17 (28%) 25 (41%) 2 (3%) 17 (28%) |
ns ns ns < 0.01 |
Valvular
heart disease |
3 (3%) |
3 (3%) |
3 (5%) |
ns |
Marginal
donors (total) High
dose inotropes Age
≥ 50 years LV
dysfunction Ischemic
time > 360 min |
44 (44%) 30 (30%) 9 (9%) 10 (10%) 4 (4%) |
59 (57%) 32 (31%) 24 (23%) 11 (11%) 4 (4%) |
34 (56%) 20 (33%) 15 (25%) 8 (13%) 1 (2%) |
ns ns < 0.01 ns ns |
PROCEDURAL
FACTORS |
|
|
|
|
Ischemic
time (min, mean ± SD) |
235 ± 68 |
232 ± 67 |
216 ± 63 |
ns |
Ischemic
time > 240 min (n, %) |
43 (43%) |
42 (40%) |
20 (33%) |
ns |
Cross-clamp
time (min, mean ± SD) |
82 ± 20 |
83 ± 24 |
111 ± 36 |
< 0.0001 |
Female
to male transplants (n, %) |
13 (13%) |
16 (15%) |
8 (13%) |
ns |
Donor
: Recipient weight
< 0.8 (n, %) |
3 (3%) |
10 (10%) |
2 (3%) |
ns |
Urgent
transplant (n,%) |
2 (2%) |
5 (5%) |
3 (5%) |
ns |
RECIPIENT
FACTORS |
|
|
|
|
Recipient
age (years, mean ± SD) |
48 ± 12 |
48 ± 13 |
46 ± 13 |
ns |
Recipient
weight (kg, mean ± SD) |
76 ± 14 |
73 ± 15 |
74 ± 17 |
ns |
MCS
(n,
%) (LVAD,
BiVAD or TAH) |
6 (6%) |
23 (22%) |
22 (36%) |
< 0.0001 |
ECMO
or IABP pre-transplant
(n,
%) |
1 (1%) |
0 |
0 |
ns |
Congenital
heart disease (n, %) |
4 (4%) |
6 (6%) |
3 (5%) |
ns |
Redo
sternotomy (n, %) |
34 (34%) |
36 (35%) |
29 (48%) |
ns |
Multiorgan
transplant Heart-Lung Heart-Kidney |
1 (1%) 1 (1%) |
3 (3%) 1 (1%) |
2 (3%) 0 |
ns ns |
Recipient
PHT# |
23 (23%) |
22 (21%) |
13 (21%) |
ns |
Retransplant |
0 |
0 |
0 |
ns |
ŘAnoxic brain death
(asthma, hanging), cerebral edema from overdoses and meningitis.
# Recipient pulmonary hypertension was defined
by a transpulmonary gradient ≥ 12 mmHg.
STS indicates St. Thomas’ Solution; EPO: Erythropoietin;
GTN: Glyceryl trinitrate; CVA: Cerebrovascular accident; ICH: Intracranial Hemorrhage;
MCS: Mechanical Circulatory Support;
LVAD: Left Ventricular Assist Device; BiVAD:
Biventricular Assist Device; TAH: Total Artificial Heart; ECMO: Extra-Corporeal
Membrane Oxygenation; IABP: Intra-aortic Balloon Pump; and PHT: Pulmonary Hypertension