Table 1: Patient and transplant characteristics.
|
Chronic GVHD |
Mann-Whitney U test |
|
|
Variables |
No (n = 23) Yes (n
= 19) |
p value |
|
Age (years) |
||
|
Median
[range] |
23 [12-55] 34
[16-60] |
0.005 |
|
Gender |
||
|
Male
(%) |
18 (78) 14
(74) |
0.73 |
|
Female
(%) |
5 (22) 5
(26) |
|
|
Donor |
||
|
Related
(%) |
19 (83) 18
(95) |
0.36 |
|
Unrelated
(%) |
4 (17) 1
(5) |
|
|
Diagnosis |
||
|
Acute
leukemia (%) |
10 (43) 10
(53) |
0.56 |
|
Chronic
leukemia (%) |
2 (10) 4
(21) |
|
|
Lymphoma
(%) |
6 (26) 3
(16) |
|
|
MDS
(%) |
1 (4) 0 (0) |
|
|
Severe
aplastic anemia (%) |
4 (17) 2
(10) |
|
|
Disease status at
transplantation |
||
|
Nonmalignant
disease (%) |
4 (17) 2
(10) |
0.56 |
|
Standard
risk (%) |
5 (22) 6
(32) |
|
|
High
risk (%) |
14 (61)
11 (58) |
|
|
Source of HSC |
||
|
BM
(%) |
14 (61) 6
(32) |
0.06 |
|
PBSC
(%) |
6 (26)
13 (68) |
|
|
CR
(%) |
3 (13) 0
(0) |
|
|
Sex mismatch |
||
|
Female
donor to male (%) |
6 (26) 8
(42) |
0.27 |
|
Others
(%) |
17 (74) 11 (58) |
|
|
Disease relapse |
||
|
Yes
(%) |
10 (44) 3
(16) |
|
|
No
(%) |
13 (56) 16
(84) |
|
|
Transplant type |
||
|
Myeloablative
(%) |
20 (87) 17
(89) |
NS |
|
Reduced
intensity (%) |
3 (13) 2 (11) |
Abbreviations: MDS: Myelodysplastic Syndrome; HSC:
Hematopoietic Stem Cells; BM: Bone Marrow; PBSC: Peripheral Blood; CB: Cord
Blood; GVHD: Graft-versus-host Disease; NS: Not significant.
All donors were HLA identical (10/10)
except one (cGVHD negative) had a single locus mismatch.