Table 1: Inhibition of different HIV-1 strains by UC781 in P4/R5 cells and determination of IC50.

HIV-1

Strains

 

 

Genetic

Subtype

 

Origin

 

Co-receptor

Usage

 

Biological

Phenotype

 

IC50s of UC781 (µM)

 

        Authors

 

92RW009

A

Rwanda

R5/X4

SI

0.017 ± 0.0015

           [38]

92BR014

B

Brazil

R5/X4

SI

0.008 ± 0.0028

           [38]

98IN017

C

India

X4

SI

0.004 ± 0.0017

           [38]

92UG001

D

Uganda

R5/X4

SI

0.026 ± 0.0085

           [38]

93TH051

E

Thailand

R5/X4

SI

0.015 ± 0.0045

           [38]

93BR020

F

Brazil

R5/X4

SI

0.01   ± 0.0075

           [38]

RU570

G

Russia

R5

NSI

0.004 ± 0.0015

           [38]

YBF30

N

Cameroon

R5

NSI

0.015 ± 0.0084

           [38]

MVP5180

O

Cameroon

R5/X4

SI

0.316 ± 0.018

           [38]

Ada-M

B

USA

R5

NSI

0.007 ± 0.0043

           [39]

Bal

B

USA

R5

NSI

0.004 ± 0.001

           [39]

JR-CSF

B

USA

R5

NSI

0.003 ± 0.0002

           [39]

JR-FL

B

USA

R5

NSI

0.005 ± 0.0047

           [39]

SF-162

B

USA

R5

NSI

0.007 ± 0.003

           [39]

89.6

B

USA

R5/X4

SI

0.007 ± 0.003

           [40]

LAI

B

USA

X4

SI

0.006 ± 0.0014

           [41]

NL4-3

B

USA

X4

SI

0.007 ± 0.002

           [42]

AZTR(3)

B

USA

X4

SI

0.006 ± 0.0027

           [43]

AZTR(4)

B

USA

X4

SI

0.007 ± 0.002

           [44]

AZTR(9)

B

USA

X4

SI

0.008 ± 0.0029

           [45]

MDR-1

B

USA

X4

SI

0.006 ± 0.0076

           [46]

MDR-5

B

USA

X4

SI

0.004 ± 0.0037

           [47]

EFVR

B

USA

X4

SI

9.28  ± 0.675

           [33]

NVPR

B

USA

X4

SI

0.052 ± 0.008

           [33]

UCR

B

USA

X4

SI

3.26  ± 0.443     

           [33]