Table 1: Inhibition of different HIV-1 strains by UC781 in P4/R5 cells and determination of IC50.
HIV-1 Strains
|
Genetic Subtype
|
Origin
|
Co-receptor Usage
|
Biological Phenotype
|
IC50s of UC781 (µM)
|
Authors
|
92RW009 |
A |
Rwanda |
R5/X4 |
SI |
0.017 ± 0.0015 |
[38] |
92BR014 |
B |
Brazil |
R5/X4 |
SI |
0.008 ± 0.0028 |
[38] |
98IN017 |
C |
India |
X4 |
SI |
0.004 ± 0.0017 |
[38] |
92UG001 |
D |
Uganda |
R5/X4 |
SI |
0.026 ± 0.0085 |
[38] |
93TH051 |
E |
Thailand |
R5/X4 |
SI |
0.015 ± 0.0045 |
[38] |
93BR020 |
F |
Brazil |
R5/X4 |
SI |
0.01 ± 0.0075 |
[38] |
RU570 |
G |
Russia |
R5 |
NSI |
0.004 ± 0.0015 |
[38] |
YBF30 |
N |
Cameroon |
R5 |
NSI |
0.015 ± 0.0084 |
[38] |
MVP5180 |
O |
Cameroon |
R5/X4 |
SI |
0.316 ± 0.018 |
[38] |
Ada-M |
B |
USA |
R5 |
NSI |
0.007 ± 0.0043 |
[39] |
Bal |
B |
USA |
R5 |
NSI |
0.004 ± 0.001 |
[39] |
JR-CSF |
B |
USA |
R5 |
NSI |
0.003 ± 0.0002 |
[39] |
JR-FL |
B |
USA |
R5 |
NSI |
0.005 ± 0.0047 |
[39] |
SF-162 |
B |
USA |
R5 |
NSI |
0.007 ± 0.003 |
[39] |
89.6 |
B |
USA |
R5/X4 |
SI |
0.007 ± 0.003 |
[40] |
LAI |
B |
USA |
X4 |
SI |
0.006 ± 0.0014 |
[41] |
NL4-3 |
B |
USA |
X4 |
SI |
0.007 ± 0.002 |
[42] |
AZTR(3) |
B |
USA |
X4 |
SI |
0.006 ± 0.0027 |
[43] |
AZTR(4) |
B |
USA |
X4 |
SI |
0.007 ± 0.002 |
[44] |
AZTR(9) |
B |
USA |
X4 |
SI |
0.008 ± 0.0029 |
[45] |
MDR-1 |
B |
USA |
X4 |
SI |
0.006 ± 0.0076 |
[46] |
MDR-5 |
B |
USA |
X4 |
SI |
0.004 ± 0.0037 |
[47] |
EFVR |
B |
USA |
X4 |
SI |
9.28 ± 0.675 |
[33] |
NVPR |
B |
USA |
X4 |
SI |
0.052 ± 0.008 |
[33] |
UCR |
B |
USA |
X4 |
SI |
3.26 ± 0.443 |
[33] |