Table 1: Key Studies that Investigated NRTI-Associated Macrocytosis.

 

Authors

Study design

Population (n)

NRTI(s) assessed (n)

NRTI(s) Associated with Macrocytosis

Romanelli et al. [4]

Retrospective, single-center chart review

HIV-infected patients (164)

AZT (71)

AZT

GennÚ et al. [6]

Retrospective, single-center cohort study

Cases with macrocytosis (30)

ddI (4/30)

d4T

Controls without macrocytosis (60)

d4T (28/30)

Eyer-Silva et al. [11]

Retrospective, single-center study

A: AZT- na´ve (81)

d4T (115)

d4T

B: AZT-experienced (34)

All Patients on d4T

Khawcharoenporn et al. [12]

Retrospective, single-center study

60 HIV-infected patients not on AZT or d4T

3TC (n/r)

3TC

ABC (n/r)

TDF (n/r)

Petersen et al. [14]

Retrospective, multicenter chart review

590 HIV-infected patients

All AZT (527)

AZT

AZT monotherapy (412)

d4T

All d4T (40)

3TC

All 3TC (139)

 

All ddI (28)

 

ddI monotherapy (11)

 

Diop et al. [15]

Retrospective, transversal study

112 HIV-infected patients

3TC (150)

AZT

d4T (21)

d4T

AZT (83)

3TC

ABC (84)

 

TDF (60)

 

ddI (33)

 

Steele et al. [17]

Retrospective, single-center chart review

61 HIV-infected patients

3TC (8)

AZT

AZT (30)

d4T

d4T (41)

3TC

Volberding et al. [22]

Double-blind, multicenter, placebo controlled trial

1637 HIV-infected patients

AZT (1090)

AZT

Placebo (547)

Richman et al. [27]

Double-blinded, placebo controlled trial

278 HIV-infected patients

AZT (143)

AZT

Placebo (135)

Ahmad et al. [33]

Retrospective, single-center case series

17 HIV-infected patients

d4T

d4T

Martin et al. [31]

Retrospective, single-center chart review

91 HIV-infected patients

d4T

d4T