Table 1: End of AIDS, Epidemiologic control, HIV control, HIV elimination, HIV eradication and HIV extinction*.

Category Definition Examples
End of AIDS (political) Abstract political target of ending HIV as a major public health problem Commonly used in political and public health discourse
End of AIDS (epidemiological) Reduction of HIV incidence and AIDS to below one AIDS case per 1000 population [23]. The 90-90-90 and 95-95-95 targets are milestones on the way to the end of AIDS as they translate into 73% and 86% of people being virally suppressed, respectively [37]. The Global Plan calls for the elimination of maternal to child transmission to less than 5% transmission [35] Leadership in New York State [44], Cambodia [45], San Francisco [46], Vancouver [47] are focused on HIV control, ending AIDS and getting to zero new infections
Epidemiologic Control The point at which new HIV infections have decreased and fall below the number of AIDS-related deaths PEPFAR 3.0
HIV control The reduction of HIV disease incidence, prevalence, morbidity, or morality to a locally acceptable level as the result of deliberate public health efforts; continued interventions will be needed to maintain the reduction and move towards elimination targets San Francisco, Vancouver,
HIV elimination Reduction of HIV and AIDS in a defined geographical area to below one AIDS case per 10,000 population per year and a reduction of HIV incidence to 1 new case per 10,000 population [23]. HIV-associated TB 1-5 per 1000 PLHIV per year. Deaths 5 per 1000 people living with HIV per year. Continued intervention measures including treatment are required to maintain elimination. Cambodia
HIV eradication Permanent reduction to zero of the worldwide incidence of HIV because of deliberate efforts. Intervention measures are no longer needed None
HIV extinction The specific agent no longer exists in the laboratory or nature; interventions are no longer needed None

*Table adapted from the Bulletin of the World Health Organization (1988) The principles of disease elimination and eradication [41].