Table 1: Summary of patient labs and imaging.

Date Lab
1998 HBsAg (+), HBV DNA < 0.0004 pg/mL
10/1999 Pt sustained severe car accident with multiple severe injuries, requiring surgeries and blood transfusion
10/2000 HBV DNA < 0.01 pg/mL

ALT 145 IU/L could have been due to HCV but anti-HCV was not tested

11/2000 HBsAg (+), anti-HBs (-), anti-HBc (+), HBeAg (-)/anti-HBe (-)

ALT 35 IU/L

AFP 4 ng/mL

Abdominal ultrasound: Liver with normal and homogeneous parenchyma

No return for 9 years
7/2009

Sent by FMD for abnormal ALT

ALT 163 U/L

HBsAg (+), anti-HBs (-), HBeAg (-)/anti-HBe (-)

HBV DNA undetectable (< 100 IU/ml)

AFP 7.2 ng/ml

Abdominal MRI: Moderate to severe hepatic steatosis with no evidence of cirrhosis or HCC

9/2009 HBV DNA < 29 IU/mL
3/2010 ALT 71 IU/L

Since ALT continued elevated with negative HBV DNA, HCV was tested: Anti-HCV (+) with HCV RNA 1.75 × 104 IU/ml, HCV genotype 2

HBV DNA < 29 IU/m,

Platelets 160 × 103/µL

PegIFN + Ribavirin treatment for 6 months (9/2010-3/2011)

7/2011 HCV RNA (< 43 IU/ml) and HBV DNA (< 169 IU/ml)
10/2011 Abdominal MRI: 1.6 × 1.6 cm lesion in segment 8 that had T2 hyperintensity, arterial enhancement and washout consistent with HCC, minimally cirrhotic appearing liver

AFP 2.8 ng/ml

ALT 40 IU/L

Platelets 200 × 103/µL

HBV DNA: 8.9 × 104 copies/ml (from a special lab)