Table 2: Classification of different MMPs on substrate specificity.
| MMPs | Substrates | ||
| Collagenases | MMP-1 (Collagenase 1) | Collagens type I, II, III,VII, VIII, X and XI, gelatin, fribronectin, vitronectin, laminin, entactin, tenascin, aggrecan, link protein, myelin basic protein, versican | |
| MMP-8 (Collagenase 2) | Collagens type I, II and III, aggrecan | ||
| MMP-13 (Collagenase 3) | Collagens type I, II, III, IV, VI, IX, X and XIV, collagen telopeptides, gelatin, fibronectin, SPARC, aggrecan, perlecan, large tenascin-C | ||
| MMP-18 (Collagenase 4) | Collagen type I (rat) | ||
| Gelatinases | MMP-2 (Gelatinase A) | Collagens type I, II, III, IV, V, VII, X and XI, gelatin, elastin, fibronectin, vitronectin, laminin, entactin, tenascin, SPARC, aggrecan, link protein, galectin-3, versican, decorin, myelin basic protein | |
| MMP-9 (Gelatinase B) | Collagens type IV, V, X and XIV, gelatin, elastin, vitronectin, laminin, entactin, tenascin, SPARC, aggrecan, link protein, galectin-3, versican, decorin, myelin basic protein | ||
| Stromelysins | MMP-3 (Stromelysin 1) | Collagens type III, IV, IX, X and XI, collagen telopeptides, gelatin, elastin, fibronectin, vitronectin, laminin, entactin, tenascin, SPARC, aggrecan, link protein, decorin, myelin basic protein, perlecan, versican, fibulin | |
| MMP-10 (Stromelysin 2) | Collagens type III, IV and V, gelatin, elastin, fibronectin, aggrecan, link protein | ||
| MMP-11 (Stromelysin 3) | Collagens type IV, gelatin, fibronectin, laminin | ||
| Matrilysins | MMP-7 (Matrilysin 1) | Collagens type I and IV, gelatin, elastin, fibronectin, vitronectin, laminin, entactin, tenascin, SPARC, aggrecan, link protein, decorin, myelin basic protein, fibulin, versican | |
| MMP-26 (Matrilysin 2) | Collagens type IV, gelatin, fibronectin, vitronectin | ||
| Membrane-type MMPs | Trans-membrane | MMP-14(MT1-MMP) | Collagens type I, II and III, gelatin, fibronectin, tenascin, vitronectin, laminin, entactin, aggrecan, perlecan |
| MMP-15(MT2-MMP) | Fibronectin, tenascin, entactin, laminin | ||
| MMP-16(MT3-MMP) | Collagens type III, gelatin, fibronectin, vitronectin, laminin | ||
| MMP-24(MT4-MMP) | Fibronectin, gelatin, chondroitin sulphate proteoglycan, dermatan sulphate proteoglycan | ||
| GPI-anchored | MMP-14(MT1-MMP) | Gelatin | |
| MMP-15(MT2-MMP) | Collagens type IV fibronectin, gelatin, chondroitin sulphate proteoglycan, dermatan sulphate proteoglycan | ||