Table 2: Classification of different MMPs on substrate specificity.

MMPs Substrates
Collagenases MMP-1 (Collagenase 1) Collagens type I, II, III,VII, VIII, X and XI, gelatin, fribronectin, vitronectin, laminin, entactin, tenascin, aggrecan, link protein, myelin basic protein, versican
MMP-8 (Collagenase 2) Collagens type I, II and III, aggrecan
MMP-13 (Collagenase 3) Collagens type I, II, III, IV, VI, IX, X and XIV, collagen telopeptides, gelatin, fibronectin, SPARC, aggrecan, perlecan, large tenascin-C
MMP-18 (Collagenase 4) Collagen type I (rat)
Gelatinases MMP-2 (Gelatinase A) Collagens type I, II, III, IV, V, VII, X and XI, gelatin, elastin, fibronectin, vitronectin, laminin, entactin, tenascin, SPARC, aggrecan, link protein, galectin-3, versican, decorin, myelin basic protein
MMP-9 (Gelatinase B) Collagens type IV, V, X and XIV, gelatin, elastin, vitronectin, laminin, entactin, tenascin, SPARC, aggrecan, link protein, galectin-3, versican, decorin, myelin basic protein
Stromelysins MMP-3 (Stromelysin 1) Collagens type III, IV, IX, X and XI, collagen telopeptides, gelatin, elastin, fibronectin, vitronectin, laminin, entactin, tenascin, SPARC, aggrecan, link protein, decorin, myelin basic protein, perlecan, versican, fibulin
MMP-10 (Stromelysin 2) Collagens type III, IV and V, gelatin, elastin, fibronectin, aggrecan, link protein
MMP-11 (Stromelysin 3) Collagens type IV, gelatin, fibronectin, laminin
Matrilysins MMP-7 (Matrilysin 1) Collagens type I and IV, gelatin, elastin, fibronectin, vitronectin, laminin, entactin, tenascin, SPARC, aggrecan, link protein, decorin, myelin basic protein, fibulin, versican
MMP-26 (Matrilysin 2) Collagens type IV, gelatin, fibronectin, vitronectin
Membrane-type MMPs Trans-membrane MMP-14(MT1-MMP) Collagens type I, II and III, gelatin, fibronectin, tenascin, vitronectin, laminin, entactin, aggrecan, perlecan
MMP-15(MT2-MMP) Fibronectin, tenascin, entactin, laminin
MMP-16(MT3-MMP) Collagens type III, gelatin, fibronectin, vitronectin, laminin
MMP-24(MT4-MMP) Fibronectin, gelatin, chondroitin sulphate proteoglycan, dermatan sulphate proteoglycan
GPI-anchored MMP-14(MT1-MMP) Gelatin
MMP-15(MT2-MMP) Collagens type IV fibronectin, gelatin, chondroitin sulphate proteoglycan, dermatan sulphate proteoglycan