MMPs, ADAMs and TIMPs expression and role in inflammatory bowel disease (IBD)

Table 3: MMPs, ADAMs and TIMPs expression and role in inflammatory bowel disease (IBD).

MMPsG3:I20, ADAMs and TIMPs	Expression in IBD	Role in IBD
MMP-1	↑	Potentiates the in lammatory response Ulceration (UC) Biomarker of disease stage (UC)
MMP-13	↑	TNFα cleavage Mucosal damage
MMP-2	↑	Maintenance of intestinal epithelial barrier integrity Fistulae formation (CD)
MMP-9	↑	Mucosal damage Fistulae formation (CD) Angiogenesis Supportive biomarker for diagnosis of UC and CD and the disease stage
MMP-3	↑	Mucosal damage (UC) Fistulae formation (CD) Biomarker of disease stage
MMP-10	↑	ntestinal wound healing I
MMP-7	↑	Intestinal wound healing. Biomarker of disease stage in UC
MMP-26	↑	Mucosal damage and neutrophil migration
MMP-12	↑	Immune response
MMP-19	N.D	Increase of in lammatory state and mucosal damage
MMP-28	↓	Not involved.
ADAM-17	↑	TNFα cleavage Mucosa repair Colitis resistance? Neutrophil migration and colitis?
TIMP-1	↑	Biomarker of disease stage
TIMP-2	?	Not involved
TIMP-3	↓	TNFα cleavage deregulation
TIMP-4	↓	Increase of MMP-2 activity Increase of platelet aggregation

↑ : Increase; ↓: Decrease; ?: Contradictory data; N.D.: No data to our knowledge.
MMP: Matrix Metalloproteinase; ADAM: A Disintegrin and Metalloproteinase; TIMP: Tissue Inhibitors of MMPs; UC: Ulcerative Colitis; CD: Crohn's Disease.