Table 1: Summary of the 4 major studies evaluating the risk factors
and outcomes of AKI development in patients with H1N1 Influenza A infection.
|
|
Bagshaw et al. [18] |
Martin-Loeches et al. [20] |
Jung et al. [21] |
Nin et al. [23] |
|
Country |
Canada |
Spain |
South Korea |
Argentina,
Uruguay and Chile |
|
Study |
Prospective
multicenter |
Prospective
multicenter |
Retrospective multicenter |
Retrospective |
|
Total # pts |
562 |
661 |
221 |
84 |
|
%Pts with AKI |
60.9% |
17.7% |
29% |
51% |
|
# of pts with AKI |
342 |
118 |
50 |
43 |
|
Characteristics of AKI patients |
||||
|
Age |
49.1 (15.1) |
44.9 (15.2) |
66 (53-73) |
46 (13) |
|
Male (%) |
165 (48.2) |
77 (65.3) |
26 (52) |
30(72) |
|
Body mass index(kg/m²) % BMI>30 |
118(34.5) |
- 52 (44.4) |
22.6(4.3) - |
33(2) - |
|
Diabetes (%) |
107(31.3) |
19 (16.2) |
16(32) |
- |
|
COPD (%) |
56(16.4) |
19 (16.2) |
10(20) |
- |
|
CKD (%) |
44(12.9) |
Excluded |
3(6) |
- |
|
APACHE II Score Mean(± SD) Median (IQR ) |
23.0(9.6) |
19.1 (8.4) |
25.1 ± 7 |
20(7) |
|
SOFA Score Mean (± SD) |
12.0(3.8) |
8.7(4.2) |
10.6 ± 3 |
- |
|
ICU stay Mean (± SD) Median (IQR) |
- 12(7-24) |
19.4(16.5) 13 (7-30) |
19.9 ± 11.4 - |
- 11(5-16) |
|
Hospital stay Mean (± SD) Median (IQR) |
- 20(12-40) |
30.3(19.9) 26.5(13.7-44.2) |
26 ± 36.4 - |
- 18(11-34) |
|
Inotropic support (%) |
222(64.9) |
89(75.4) |
42(84) |
- |
|
Renal replacement therapy (%) |
85(24.9) |
50(42.3) |
19(38) |
19(44) |
|
AKI Criteria |
RIFLE |
AKIN |
RIFLE |
RIFLE |
|
Mortality (%) |
85(25.8) (Hospital) |
52(44.1) (ICU) |
38(76) (Hospital) |
31(72) (ICU) |
*AKI: Acute Kidney Injury, COPD: Chronic Obstructive Pulmonary disease,
CKD: Chronic Kidney Disease, APACHEII: Acute Physiology and Chronic Health Evaluation
II, SOFA: Sequential Organ Failure Assessment, ICU: intensive care unit,
Categorical data are presented as n(%) and continuous data as mean(SD) or
median(Q1-Q3)