Characteristics

Sickle Cell Anemia

n = 81 (%)

Sickle Cell Trait

n = 26 (%)

p-value

Gender

Male sex n (%)

50 (62)

12 (36)

0.162

Age (years)

Median [interquartile]

18 [15-24]

35 [28-44]

< 0.001

Comorbidities

Used of NSAID

21 (26)

-

-

Hypertension

0

0

-

Diabetes

0

0

-

HBV/HCV

0

0

-

HIV

0

1

-

Sickle cell anemia characteristics

Vaso-occlusive crisis

59 (55)

-

Aseptic osteonecrosis

10 (12.3)

-

Retinopathy

12 (15)

-

Leg ulcer

10 (12.3)

-

Used of Hydroxyurea

8 (10)

-

Unit of blood per years

Median [interquartile])

3 [2-4]

-

Usual hemoglobin level

7.19 ± 1.9 g/dl

Clinical data

Body mass index

17.75 ± 2.92

26.41 ± 3.68

< 0.001

Underweight

21 (26)

0

< 0.001

Normal weight

60 (74)

17 (65.4)

Overweight/obesity

0

9 (34.6)

Systolic blood pressure

101.91 ± 14.34

116.23 ± 17.44

Hypotension

32 (39.5)

-

< 0.001

Normal BP

48 (59.3)

23 (88.5)

Hypertension

1 (1.2)

3 (11.5)

Proteinuria

12 (15)

5 (19.2)

0.253

Leucocyturie

37 (45.7)

10 (38.5)

0.609

Hematuria

2 (2.5)

1 (3.8)

0.570

Urine density

Hyposthenuria

65(80)

9(34.6)

< 0.001

Laboratory data

Creatinine, mean ± SD (mg/l)

5.67 ± 3.38

8.38 ± 1.81

< 0.001

eGFR (ml/min/1.73 m²)

159.95 ± 51.5

118.65 ± 22.61

0.001

Normal

12 (15)

18 (69)

< 0.001

Hyperfiltration

61 (75)

8 (31)

Low

8 (10)

0