Table 1: Baseline characteristics of patients at the first consultation.
Characteristics |
Sickle Cell Anemia n = 81 (%) |
Sickle Cell Trait n = 26 (%) |
p-value |
Gender |
|||
Male sex n (%) |
50 (62) |
12 (36) |
0.162 |
Age (years) |
|||
Median [interquartile] |
18 [15-24] |
35 [28-44] |
< 0.001 |
Comorbidities |
|||
Used of NSAID |
21 (26) |
- |
- |
Hypertension |
0 |
0 |
- |
Diabetes |
0 |
0 |
- |
HBV/HCV |
0 |
0 |
- |
HIV |
0 |
1 |
- |
Sickle cell anemia characteristics |
|||
Vaso-occlusive crisis |
59 (55) |
- |
|
Aseptic osteonecrosis |
10 (12.3) |
- |
|
Retinopathy |
12 (15) |
- |
|
Leg ulcer |
10 (12.3) |
- |
|
Used of Hydroxyurea |
8 (10) |
- |
|
Unit of blood per years Median [interquartile]) |
3 [2-4] |
- |
|
Usual hemoglobin level |
7.19 ± 1.9 g/dl |
||
Clinical data |
|||
Body mass index |
17.75 ± 2.92 |
26.41 ± 3.68 |
< 0.001 |
Underweight |
21 (26) |
0 |
< 0.001 |
Normal weight |
60 (74) |
17 (65.4) |
|
Overweight/obesity |
0 |
9 (34.6) |
|
Systolic blood pressure |
101.91 ± 14.34 |
116.23 ± 17.44 |
|
Hypotension |
32 (39.5) |
- |
< 0.001 |
Normal BP |
48 (59.3) |
23 (88.5) |
|
Hypertension |
1 (1.2) |
3 (11.5) |
|
Proteinuria |
12 (15) |
5 (19.2) |
0.253 |
Leucocyturie |
37 (45.7) |
10 (38.5) |
0.609 |
Hematuria |
2 (2.5) |
1 (3.8) |
0.570 |
Urine density |
|||
Hyposthenuria |
65(80) |
9(34.6) |
< 0.001 |
Laboratory data |
|||
Creatinine, mean ± SD (mg/l) |
5.67 ± 3.38 |
8.38 ± 1.81 |
< 0.001 |
eGFR (ml/min/1.73 m2) |
159.95 ± 51.5 |
118.65 ± 22.61 |
0.001 |
Normal |
12 (15) |
18 (69) |
< 0.001 |
Hyperfiltration |
61 (75) |
8 (31) |
|
Low |
8 (10) |
0 |
HBV: Hepatitis B virus; HCV: Hepatitis C virus; HIV: Human immunodeficiency virus; NSAID: Non-steroidal anti-inflammatory drug; SD: Standard deviation; eGFR: Estimated glomerular filtration rate.