Table 2: Colorectal Cancer Screening Tests.

Screening modality

Sensitivity

Specificity

 

Cost per test

US dollars

Serious Complications

Advanced Adenoma

Cancer

FOBT

17.7%-49.4%

50.0-87.0%

90.0-95.0%

$8-$23

NS

FIT

16.0-48.0%

71.0-87.0%

92.5-98.0%

$13-$40

NS

sDNA

42.4-44.6%

92.3-92.6%

83.8-89.8%

$400-$800

NS

CT Colonography

83.3%-93.0%

93.3%-96.5%

89.0%-96.5%

$400-$800

0-6/10,000

Sigmoidoscopy

71.3%-85.6%

58.3%-75.0%

89.0-95.0%

$169-$507

3.4/10,000

Colonoscopy

85.0%-95.0%

92.0%-97.0%

90.0-100%

$645-$1013

25/10,000

 

FOBT: high sensitivity guiac fecal occult blood test (Hemoccult Sensa); FIT: fecal immunochemical test; sDNA: multi-target stool DNA test (Cologuard); DCBE: double-contrast barium enema; CT: computed tomography; Advanced adenoma: adenomas ≥ 10 mm.

Serious complications: deaths or hospitalizations from perforation, major bleeding, diverticulitis, severe abdominal pain, and cardiovascular events.

NS: estimated to be non-significant although evidence lacking