Literature review of tongue necrosis in granulomatosis with polyangiitis.

Table 3: Literature review of tongue necrosis in granulomatosis with polyangiitis.

Ref	Age/Sex	Trigger	ESR/CRP	Presenting Symptoms	Diagnostic features/tests	Treatment
31	56/F	No	CRP elevated	HA, sinus pain, shortness of breath, productive cough, tongue infarction anterior 2/3 bilaterally	ANCA PR-3: 18 U/mL ANCA MPO: 1 u/mL Renal failure with pulmonary hemorrhage	High-dose steroids
32	58/F	No	NR	Shortness of breath, pain on left-side of tongue	ANCA PR-3: 200 U/mL Renal failure with pulmonary hemorrhage Biopsy of cutaneous ulcers: fibrinoid necrosis	High-dose steroids High-dose steroids + cyclophosphamide

Ref: Reference, F: Female, CRP: C-Reactive Protein, NR: Not Reported, HA: Headache, PR-3: Proteinase-3 Antibodies, MPO: Myeloperoxidase Antibodies.