Table 1: Presence of iron element on the human body and its functions.

Iron Containing proteins Compounds % of Iron Indicadores de Salud, 2013 [4] Body Localization Function
Heme Group Haemoglobin 68 Erythrocytes O2 Transport
Myoglobin 4 Muscle O2 storage in the muscle for its contraction
Cytochromes a,b,c (oxidases) and subtypes 0.6 Internal mitochondrial membrane


Oxidative process in ATP form

Oxidase pyruvate-malate Mitochondria
Succinic oxidase
Cytochrome c reductase
Succinate-cythocrome c reductase Enzymes in rat's heart mitochondria
Succinic dehydrogenase Mitochondrial
NADH ferricyanide oxidoreductase
α-glycerophosphate oxidase
Cytochrome P450 0.6 Membrane of the endoplasmatic Reticulum in liver Catabolics enzymes
Catalases Cells Transforms hydrogen peroxide in oxygen and water: antioxidant processes
Peroxidases Immune cells, and others Eliminates hydrogen peroxide; oxidation processes; Activate pathways of the nonspecific immune answer
Prostaglandin synthase Liver, mainly Synthesis of Prostaglandins
Guanylate cyclase Cells Activate cAMP, 2nd messenger mainly by activating intracellular protein kinases activated in response to peptide hormones
Nitrous oxide generating enzymes: nitric oxide synthase Cellular cytoplasm, central nervous system, skeletal and cardiac muscle, immune cells Synthesizes nitric oxide, cell communication, immune system, cardiovascular, vasodilation
Heme Group Lactoferrin 0.6 Immune cells in breast milk Granulocytes: activate nonspecific immune response pathways
Myeloperoxidase [1,4] Neutrophils Oxide reactive substances involved in non-specific immune response.
MAOS: [1-4] Monoamine Oxidases: Neurons; platelets and adrenal gland Synthesizes of neurotransmitters and catecholamine
Tryptophan hydroxylase Synthesizes of serotonin
Tyrosine hydrolase Synthesizes of norepinephrine and dopamine
GABA [1,2,5] transaminase: γ-aminobutyric acid and glutamate decarboxylase Central nervous system Synthesizes of GABA and the glutamate
T4-5'Deiodinase [9] Cells Enzyme conversion of T4 to T3 (thyroxine to triioditironina)
Protohemomonooxigenases [1] Oligodendrocytes Myelin production
Non-heme Group Metalloflavoproteins: 1-Xanthine-oxidase; Mitochondria [4] The Krebs Cycle
2-NADH deshydrogenases;
3-Succinic deshydrogenases
4-α-glycerophosphate deshydrogenase;
Ribonucleotide reductase Cells with mitosis Cellular replication and processes of mitosis [4]
Iron as cofactor Ferredoxins (3000 millon) [10] Mitochondria Electrons transport in oxidation-reduction
Aconitase [11] Mitochondrial cytoplasm Tricarboxylic acid cycle: the Krebs cycle
Proline and lysine hydroxylase [13] Cellular cytoplasm Synthesis of Collagen
Aldehyde oxidase [4] Xanthine-oxidases family; cellular cytoplasm Route of reactive oxygen formation, cellular redox processes
Tryptophanpyrrolase, tryptophan 2,3-Dioxygenase (TDO), or tryptophan oxygenase [4] Central nervous system Tryptophan metabolism pathway kynurenine: INF γ picolinic acid stimulates macrophages
Metabolic of iron Iron Response Element (IRE) (there are 70 known) [3] Hepatocytes, reticuloendothelial and musculoskeletal, crystalline mRNA translation in iron metabolism
Transferrin 0.1 Blood and glial cells Iron transport and storage in glial cells
Ferritin subunit H [1,13,14] 27% tissue; 0.004 in serum Blood, heart and central nervous system cells Iron storage
Ferritin subunit L [1,4,7] Crystalline, liver, spleen