Table 1: Association between improvement of disease after HU treatment and the presence of the polymorphic site (C>T) at position -158 Xmn I at the G-? promoter region in the S/S (i) and S/ (ii) cohorts

S/S patients T/T (%) (n=11) T/C (%) (n=6) C/C (%) (n=23)
Good responders 91% (n=10) 83.3% (n=5) -
Partial responders 9% (n=1) 16.7% (n=1) 82.6% (n=19)
Non responders - - 17.4% (n=4)


S/ patients T/C (%) (n=5) C/C (%) (n=7)
Good responders 60% (n=3) 14.3% (n=1)
Partial responders 20% (n=1) 71.4% (n=5)
Non responders 20% (n=1) 14.3% (n=1)