Table 2: KIR receptor-HLA ligand association among cytomegalovirus and noncytomegalovirus infected renal transplantation cases.



HLA KIR CMV Non-CMV p-value O.R. 95% CI
C1/C1 KIR2DL2+ 6/14 (42.8%) 69/111 (62.1%) 0.2462 0.45 0.14-1.40
KIR2DL3+ 7/22 (31.8%) 64/200 (32.0%) 1.0000 0.99 0.38-2.55
KIR2DS2+ 3/10 (30.0%) 27/82 (32.9%) 1.0000 0.87 0.20-3.64
KIR2DS3+ 2/9 (22.2%) 27/72 (37.5%) 0.4783 0.47 0.09-2.46
C2/C2 KIR2DL1+ 3/24 (12.5%) 38/226 (16.8%) 0.7751 0.70 0.20-2.49
KIR2DS1+ 6/10 (6.0%) 42/101 (41.5%) 0.3243 2.10 0.55-7.93
C1/C2 KIR2DL2+ 5/14 (35.7%) 30/111 (27.0%) 0.5332 1.50 0.46-4.83
KIR2DL3+ 8/22 (36.3%) 70/200 (35%) 1.0000 1.06 0.42-2.65
KIR2DS2+ 5/10 (50.0%) 32/82 (39.0%) 0.5158 1.56 0.41-5.83
KIR2DS3+ 4/9 (44.4%) 30/72 (41.6%) 1.0000 1.12 0.27-4.52
KIR2DL1+ 10/24 (41.6%) 81/226 (35.8%) 0.6566 1.27 0.54-3.01
KIR2DS1+ 4/10 (4.0%) 36/101 (35.6%) 0.7451 1.20 0.31-4.54
Bw4/Bw4 KIR3DL1+ 12/21 (57.1%) 152/206 (73.7%) 0.1255 0.47 0.18-1.18
KIR3DS1+ 9/15 (60.0%) 69/135 (51.1%) 0.5926 1.43 0.48-4.25
Bw6/Bw4 KIR3DL1+ 9/21 (42.8%) 54/206 (26.1%) 0.1255 2.11 0.84-5.29
KIR3DS1+ 6/15 (40.0%) 66/135 (48.8%) 0.5926 0.69 0.23-2.06
Combinatorial Analysis
Bw4/4 + Bw4/6 KIR3DL1+ 14(52%) 149(75%) 0.0201* 0.60 0.40-0.92
KIR3DS1+ 10(42%) 73(39%) 0.4619 1.20 0.75-1.92
Bw4/4 + Bw6/6 KIR3DL1+ 9(36%) 91(45%) 0.3534 0.78 0.49-1.26
KIR3DS1+ 7(29%) 41(20%) 0.1744 1.52 0.87-2.65


*=p< 0.05 & statistically significant. No significance was obtained for HLA C1/ C1 + C1/C2, HLA C2/C2 + C1/C2 and HLA C1/C1 + C2/C2 combinations when compared with their respective KIR receptors.