Table 2: Associations between Genotyped SNPs in Circadian Genes and EOC Incidence Overall, in Histological Subtypes, and Invasiveness.

 

 

 

 

 

All invasive

 

Serous

 

Clear cell

 

Gene

SNP

Chr

Min/Maj

MAF

OR (95% CI)

p

OR (95% CI)

p

OR (95% CI)

p

BMAL1

rs1026071

11

G/A

0.30

0.98 (0.95-1.01)

2.26 10-01

1.00 (0.96-1.04)

9.38 10-01

0.88 (0.8-0.98)

1.55 10-02

BMAL1

rs10732458

11

A/G

0.02

1.11 (0.99-1.23)

6.91 10-02

1.10 (0.96-1.25)

1.64 10-01

1.19 (0.88-1.6)

2.52 10-01

BMAL1

rs10832027

11

G/A

0.33

0.98 (0.95-1.02)

3.48 10-01

1.00 (0.96-1.04)

9.79 10-01

0.92 (0.84-1.01)

9.15 10-02

BMAL1

rs1562438

11

A/G

0.29

0.98 (0.95-1.02)

3.07 10-01

1.00 (0.96-1.05)

8.46 10-01

0.88 (0.80-0.97)

1.35 10-02

BMAL1

rs16912751

11

G/A

0.05

0.98 (0.92-1.05)

6.23 10-01

0.96 (0.88-1.04)

3.42 10-01

1.13 (0.93-1.37)

2.18 10-01

BMAL1

rs2896635

11

T/A

0.33

0.98 (0.95-1.02)

3.14 10-01

1.00 (0.96-1.04)

9.57 10-01

0.93 (0.84-1.02)

1.17 10-01

BMAL1

rs3789327

11

G/A

0.48

1.01 (0.98-1.04)

5.34 10-01

1.01 (0.97-1.04)

7.88 10-01

1.04 (0.95-1.14)

4.17 10-01

BMAL1

rs3816360

11

A/G

0.34

1.00 (0.96-1.03)

7.75 10-01

1.02 (0.98-1.06)

4.36 10-01

0.91 (0.82-1.00)

4.31 10-02

BMAL1

rs4757151

11

A/G

0.47

1.00 (0.97-1.04)

7.76 10-01

1.01 (0.98-1.05)

5.46 10-01

0.97 (0.89-1.06)

5.20 10-01

BMAL1

rs6486122

11

G/A

0.32

0.98 (0.95-1.02)

2.83 10-01

1.00 (0.96-1.04)

9.53 10-01

0.92 (0.83-1.01)

8.10 10-02

BMAL1

rs7117836

11

A/G

0.02

1.10 (0.99-1.22)

8.49 10-02

1.09 (0.96-1.24)

1.65 10-01

1.19 (0.89-1.59)

2.46 10-01

BMAL1

rs7947951

11

A/G

0.32

0.99 (0.95-1.02)

3.60 10-01

1.00 (0.96-1.04)

9.13 10-01

0.92 (0.84-1.01)

9.30 10-02

CRY2

rs11038695

11

A/G

0.08

1.05 (0.99-1.11)

1.11 10-01

1.03 (0.97-1.11)

3.40 10-01

0.99 (0.84-1.17)

9.25 10-01

CSNK1E

rs135750

22

G/C

0.15

1.04 (1.00-1.09)

6.14 10-02

1.03 (0.98-1.08)

3.12 10-01

1.00 (0.89-1.13)

9.73 10-01

KLF10

rs12547834

8

G/A

0.07

0.96 (0.90-1.02)

1.43 10-01

0.94 (0.88-1.02)

1.20 10-01

1.02 (0.85-1.21)

8.49 10-01

KLF10

rs3191333

8

A/G

0.37

1.04 (1.01-1.07)

2.42 10-02

1.05 (1.02-1.10)

6.72 10-03

1.04 (0.95-1.14)

3.95 10-01

KLF10

rs980112

8

A/G

0.10

0.97 (0.92-1.02)

1.98 10-01

0.96 (0.90-1.03)

2.42 10-01

1.06 (0.92-1.23)

4.08 10-01

KLF10

rs2388232

8

G/A

0.27

1.01 (0.97-1.04)

7.92 10-01

1.00 (0.96-1.04)

9.22 10-01

1.11 (1.01-1.23)

2.91 10-02

KLF10

rs2511703

8

G/A

0.43

1.04 (1.01-1.07)

1.83 10-02

1.05 (1.02-1.09)

6.54 10-03

1.00 (0.91-1.09)

9.55 10-01

KLF10

rs2513927

8

A/G

0.49

1.04 (1.01-1.07)

1.86 10-02

1.05 (1.01-1.09)

1.18 10-02

1.00 (0.91-1.10)

9.79 10-01

KLF10

rs2513928

8

G/A

0.46

0.95 (0.92-0.98)

1.75 10-03

0.94 (0.91-0.98)

2.42 10-03

0.94 (0.85-1.02)

1.50 10-01

KLF10

rs2511660

8

A/G

0.22

0.97 (0.94-1.01)

1.57 10-01

0.96 (0.92-1.00)

6.95 10-02

0.99 (0.89-1.10)

8.56 10-01

KLF10

rs2511718

8

A/G

0.12

0.98 (0.94-1.03)

4.57 10-01

0.98 (0.92-1.04)

4.47 10-01

1.06 (0.93-1.22)

3.68 10-01

NPAS2

rs1053091

2

A/G

0.02

1.05 (0.93-1.19)

4.14 10-01

1.10 (0.96-1.27)

1.83 10-01

1.12 (0.79-1.59)

5.17 10-01

NPAS2

rs13012930

2

A/G

0.17

0.96 (0.92-1.00)

4.80 10-02

0.95 (0.91-1.00)

4.11 10-02

0.98 (0.87-1.10)

6.86 10-01

NPAS2

rs3768988

2

G/A

0.06

1.01 (0.95-1.07)

8.18 10-01

1.02 (0.94-1.10)

6.44 10-01

1.01 (0.84-1.22)

9.09 10-01

NPAS2

rs7573323

2

A/G

0.03

0.97 (0.88-1.07)

5.47 10-01

0.99 (0.88-1.11)

8.61 10-01

0.87 (0.65-1.18)

3.73 10-01

PER3

rs228644

1

A/G

0.40

1.00 (0.97-1.03)

9.23 10-01

1.00 (0.96-1.03)

8.38 10-01

0.97 (0.89-1.07)

5.45 10-01

PER3

rs228682

1

G/A

0.40

1.00 (0.97-1.03)

7.83 10-01

0.99 (0.96-1.03)

7.32 10-01

0.97 (0.88-1.06)

4.84 10-01

PER3

rs228698

1

A/G

0.04

1.00 (0.93-1.08)

9.73 10-01

0.99 (0.90-1.08)

7.67 10-01

0.90 (0.71-1.14)

3.79 10-01

PER3

rs697693

1

A/G

0.19

0.99 (0.95-1.03)

5.55 10-01

0.98 (0.94-1.03)

5.02 10-01

1.07 (0.96-1.19)

2.46 10-01

REV1

rs3792152

2

A/G

0.44

0.97 (0.94-1.00)

6.47 10-02

0.97 (0.94-1.01)

1.34 10-01

0.99 (0.90-1.08)

7.96 10-01

SENP3

rs6608

17

A/G

0.17

1.05 (1.00-1.09)

3.35 10-02

1.04 (0.99-1.09)

1.42 10-01

1.01 (0.90-1.14)

8.81 10-01

TIMELESS

rs7302060

12

G/A

0.41

0.99 (0.96-1.02)

3.53 10-01

0.98 (0.94-1.01)

2.09 10-01

0.97 (0.88-1.06)

4.77 10-01

 

 

 

Endometriod

 

Mucinous

 

LMP vs. controls

 

Invasive vs. LMP

 

Gene

SNP

OR (95% CI)

p

OR (95% CI)

p

OR (95% CI)

p

OR (95% CI)

p

BMAL1

rs1026071

0.98 (0.91-1.05)

5.17 10-01

0.94 (0.85-1.05)

2.63 10-01

0.99 (0.92-1.07)

8.95 10-01

1.00 (0.92-1.08)

9.17 10-01

BMAL1

rs10732458

1.32 (1.07-1.63)

9.64 10-03

1.02 (0.72-1.44)

9.12 10-01

0.77 (0.58-1.02)

6.51 10-02

1.44 (1.09-1.92)

1.17 10-02

BMAL1

rs10832027

0.99 (0.93-1.06)

8.48 10-01

0.95 (0.86-1.05)

2.75 10-01

1.00 (0.93-1.07)

9.17 10-01

1.00 (0.92-1.07)

9.04 10-01

BMAL1

rs1562438

0.97 (0.90-1.04)

4.12 10-01

0.94 (0.85-1.05)

2.74 10-01

1.00 (0.93-1.08)

9.79 10-01

0.99 (0.92-1.07)

8.80 10-01

BMAL1

rs16912751

0.90 (0.78-1.05)

1.97 10-01

1.11 (0.91-1.36)

2.94 10-01

0.88 (0.75-1.04)

1.40 10-01

1.12 (0.95-1.33)

1.73 10-01

BMAL1

rs2896635

0.99 (0.92-1.06)

7.20 10-01

0.95 (0.86-1.05)

3.04 10-01

1.00 (0.93-1.07)

9.49 10-01

0.99 (0.92-1.07)

8.21 10-01

BMAL1

rs3789327

1.00 (0.94-1.07)

9.84 10-01

0.95 (0.86-1.04)

2.53 10-01

1.01 (0.94-1.08)

8.63 10-01

1.01 (0.94-1.08)

8.01 10-01

BMAL1

rs3816360

0.99 (0.92-1.06)

7.74 10-01

0.94 (0.85-1.04)

2.52 10-01

1.02 (0.94-1.09)

6.67 10-01

0.99 (0.92-1.06)

7.53 10-01

BMAL1

rs4757151

0.99 (0.92-1.05)

6.91 10-01

1.06 (0.97-1.17)

1.97 10-01

0.98 (0.91-1.05)

5.61 10-01

1.03 (0.96-1.11)

3.73 10-01

BMAL1

rs6486122

0.99 (0.92-1.06)

6.90 10-01

0.95 (0.86-1.05)

3.12 10-01

0.99 (0.92-1.07)

8.62 10-01

0.99 (0.92-1.07)

8.83 10-01

BMAL1

rs7117836

1.24 (1.01-1.54)

4.40 10-02

1.06 (0.76-1.48)

7.36 10-01

0.76 (0.57-1.00)

4.82 10-02

1.45 (1.09-1.92)

9.81 10-03

BMAL1

rs7947951

0.99 (0.93-1.06)

8.17 10-01

0.95 (0.86-1.05)

2.94 10-01

1.00 (0.93-1.07)

9.34 10-01

0.99 (0.92-1.07)

8.78 10-01

CRY2

rs11038695

1.09 (0.97-1.22)

1.48 10-01

0.97 (0.82-1.15)

7.19 10-01

1.07 (0.94-1.21)

2.88 10-01

0.98 (0.86-1.11)

7.02 10-01

CSNK1E

rs135750

1.13 (1.03-1.23)

7.09 10-03

1.06 (0.93-1.20)

3.90 10-01

1.02 (0.93-1.12)

6.98 10-01

1.03 (0.93-1.13)

6.10 10-01

KLF10

rs12547834

0.99 (0.87-1.13)

8.75 10-01

0.86 (0.71-1.04)

1.22 10-01

0.97 (0.84-1.11)

6.56 10-01

0.99 (0.86-1.14)

8.87 10-01

KLF10

rs3191333

1.03 (0.96-1.10)

3.84 10-01

0.95 (0.86-1.05)

3.01 10-01

0.99 (0.92-1.06)

7.70 10-01

1.05 (0.97-1.13)

2.21 10-01

KLF10

rs980112

0.95 (0.85-1.06)

3.49 10-01

0.90 (0.76-1.05)

1.85 10-01

0.99 (0.88-1.12)

8.95 10-01

0.98 (0.87-1.11)

7.73 10-01

KLF10

rs2388232

0.99 (0.92-1.06)

7.81 10-01

0.98 (0.88-1.08)

6.40 10-01

1.03 (0.96-1.12)

3.86 10-01

0.97 (0.90-1.05)

4.71 10-01

KLF10

rs2511703

1.05 (0.98-1.12)

1.34 10-01

0.95 (0.87-1.05)

3.17 10-01

0.98 (0.91-1.05)

5.75 10-01

1.06 (0.98-1.13)

1.32 10-01

KLF10

rs2513927

1.05 (0.99-1.13)

1.11 10-01

0.94 (0.85-1.03)

1.71 10-01

0.98 (0.92-1.05)

5.94 10-01

1.06 (0.99-1.13)

1.24 10-01

KLF10

rs2513928

0.95 (0.89-1.01)

1.20 10-01

1.02 (0.93-1.12)

6.88 10-01

0.96 (0.90-1.03)

2.56 10-01

0.99 (0.92-1.06)

6.95 10-01

KLF10

rs2511660

1.02 (0.94-1.10)

6.80 10-01

0.96 (0.85-1.07)

4.38 10-01

1.06 (0.98-1.15)

1.43 10-01

0.92 (0.85-1.00)

4.47 10-02

KLF10

rs2511718

0.96 (0.87-1.06)

4.28 10-01

0.95 (0.82-1.09)

4.52 10-01

1.01 (0.91-1.13)

8.02 10-01

0.97 (0.87-1.09)

6.41 10-01

NPAS2

rs1053091

0.84 (0.64-1.12)

2.45 10-01

1.02 (0.71-1.47)

9.00 10-01

1.10 (0.85-1.44)

4.69 10-01

0.93 (0.71-1.22)

5.88 10-01

NPAS2

rs13012930

1.02 (0.93-1.11)

7.23 10-01

0.91 (0.80-1.03)

1.31 10-01

1.04 (0.95-1.14)

3.73 10-01

0.92 (0.84-1.01)

9.47 10-02

NPAS2

rs3768988

0.93 (0.81-1.07)

3.02 10-01

1.01 (0.84-1.22)

8.90 10-01

1.09 (0.95-1.26)

2.06 10-01

0.93 (0.80-1.07)

2.83 10-01

NPAS2

rs7573323

0.92 (0.74-1.13)

4.13 10-01

0.83 (0.60-1.16)

2.78 10-01

0.83 (0.66-1.05)

1.12 10-01

1.18 (0.93-1.49)

1.76 10-01

PER3

rs228644

0.97 (0.91-1.04)

3.76 10-01

1.07 (0.97-1.17)

1.82 10-01

0.99 (0.92-1.06)

6.91 10-01

1.02 (0.95-1.09)

6.69 10-01

PER3

rs228682

0.97 (0.91-1.04)

3.51 10-01

1.07 (0.97-1.17)

1.90 10-01

0.98 (0.92-1.06)

6.37 10-01

1.02 (0.95-1.09)

6.65 10-01

PER3

rs228698

1.04 (0.89-1.23)

6.04 10-01

1.08 (0.86-1.36)

4.89 10-01

0.96 (0.81-1.15)

6.66 10-01

1.01 (0.85-1.21)

8.76 10-01

PER3

rs697693

0.99 (0.91-1.08)

8.61 10-01

0.92 (0.81-1.04)

1.67 10-01

1.04 (0.95-1.13)

3.81 10-01

0.96 (0.88-1.05)

3.45 10-01

REV1

rs3792152

0.92 (0.86-0.98)

9.61 10-03

0.99 (0.90-1.09)

8.32 10-01

0.98 (0.91-1.05)

4.87 10-01

1.01 (0.94-1.09)

7.65 10-01

SENP3

rs6608

1.13 (1.04-1.23)

4.43 10-03

1.00 (0.88-1.14)

9.90 10-01

1.01 (0.92-1.10)

9.00 10-01

1.04 (0.94-1.14)

4.79 10-01

TIMELESS

rs7302060

1.01 (0.95-1.08)

7.22 10-01

0.97 (0.88-1.07)

5.10 10-01

0.93 (0.87-1.00)

4.86 10-02

1.06 (0.99-1.14)

1.09 10-01

 

SNP: Single Nucleotide Polymorphism, Chr: Chromosome, Min/Maj: Minor and Major Allele, MAF: Minor Allele Frequency, LMP: Low Malignant Potential, OR: Odds Ratio

 

Note: odds ratio is calculated based on per-minor allele, bolded SNPs indicate an association of p < 0.05 with overall EOC or histologic subtype.