Table 3: Associations between the Top Imputed SNP in Each Gene with Good Imputation Quality (r2 > 0.8) and EOC Incidence Overall.

Gene

SNP

Min/Maj

MAF

OR (95% CI)

p

BMAL1

rs117104877

G/A

0.017

0.79 (0.68-0.90)

5.59 10-4

CRY2

rs10838527

G/A

0.082

1.05 (0.99-1.11)

7.66 10-2

CSNK1E

rs111427515

G/T

0.008

1.25 (1.06-1.47)

6.60 10-3

KLF10

rs2511699

A/G

0.461

0.96 (0.93-0.99)

4.13 10-3

NPAS2

rs732375

T/A

0.134

1.07 (1.02-1.11)

3.76 10-3

PER3

rs228640

A/G

0.297

1.04 (1.01-1.07)

1.24 10-2

REV1

rs3792146

T/C

0.547

1.03 (1-1.06)

2.71 10-2

SENP3

rs143094271

A/G

0.023

0.86 (0.77-0.95)

4.01 10-3

TIMELESS

rs2638286

C/T

0.030

1.05 (0.96-1.15)

2.56 10-1

 

SNP: Single Nucleotide Polymorphism, Min/Maj: Minor and Major Allele, MAF: Minor Allele Frequency, OR: Odds Ratio

 

Note: odds ratio is calculated based on per-minor allele