Cluster of hot spot residues on RAD51a interface of interaction.

Table 1: Cluster of hot spot residues on RAD51a interface of interaction.

Chain	Residue	KFC2-A^*	KFC2-B^**	Partner
A	ARG 251	0.97	0.16	PCN
F	PHE 137	0.38	0.18	PCN
F	GLN 258	0.39	0.04	PCN
F	HIS 303	1.56	0.10	PCN
G	ILE 249	1.10	0.17	PCN
G	ARG 251	0.73	0.09	PCN
G	LEU 254	0.28	0.04	PCN
A	ILE 249	1.45	0.20	FANCD2
A	ARG 251	1.68	0.28	FANCD2
E	PHE 137	1.27	0.34	FANCD2
E	ARG 251	0.93	0.10	FANCD2
E	LEU 254	0.40	0.07	FANCD2
E	GLN 258	0.69	0.06	FANCD2
E	HIS 303	1.25	0.01	FANCD2
E	ILE 304	0.39	0.11	FANCD2
E	TYR 314	1.25	0.30	FANCD2
F	ILE 249	1.14	0.15	FANCD2
F	ARG 251	1.31	0.20	FANCD2
D	LEU 254	0.97	0.13	ABL1-SH3
E	ARG 251	1.79	0.33	ABL1-SH3
E	LEU 254	1.44	0.31	ABL1-SH3
E	ARG 257	0.53	0.25	ABL1-SH3
F	ILE 249	1.34	0.26	ABL1-SH3
A	PHE 137	1.44	0.39	ABL1-TK
A	ARG 251	1.20	0.23	ABL1-TK
A	LEU 254	1.04	0.24	ABL1-TK
A	ARG 257	0.17	0.11	ABL1-TK
A	GLN 258	0.66	0.15	ABL1-TK
A	HIS 303	1.92	0.33	ABL1-TK
A	ILE 304	0.73	0.20	ABL1-TK
A	LEU 305	1.39	0.27	ABL1-TK
A	ILE 328	0.91	0.05	ABL1-TK
B	ARG 245	0.81	0.05	ABL1-TK

^*Hot spot model based on shape specificity features; ^**Hot spot model based on biochemical features such as intermolecular hydrogen bonds.