Table 1: Cluster of hot spot residues on RAD51a interface of interaction.

Chain Residue KFC2-A* KFC2-B** Partner
A ARG 251 0.97 0.16 PCN
F PHE 137 0.38 0.18 PCN
F GLN 258 0.39 0.04 PCN
F HIS 303 1.56 0.10 PCN
G ILE 249 1.10 0.17 PCN
G ARG 251 0.73 0.09 PCN
G LEU 254 0.28 0.04 PCN
A ILE 249 1.45 0.20 FANCD2
A ARG 251 1.68 0.28 FANCD2
E PHE 137 1.27 0.34 FANCD2
E ARG 251 0.93 0.10 FANCD2
E LEU 254 0.40 0.07 FANCD2
E GLN 258 0.69 0.06 FANCD2
E HIS 303 1.25 0.01 FANCD2
E ILE 304 0.39 0.11 FANCD2
E TYR 314 1.25 0.30 FANCD2
F ILE 249 1.14 0.15 FANCD2
F ARG 251 1.31 0.20 FANCD2
D LEU 254 0.97 0.13 ABL1-SH3
E ARG 251 1.79 0.33 ABL1-SH3
E LEU 254 1.44 0.31 ABL1-SH3
E ARG 257 0.53 0.25 ABL1-SH3
F ILE 249 1.34 0.26 ABL1-SH3
A PHE 137 1.44 0.39 ABL1-TK
A ARG 251 1.20 0.23 ABL1-TK
A LEU 254 1.04 0.24 ABL1-TK
A ARG 257 0.17 0.11 ABL1-TK
A GLN 258 0.66 0.15 ABL1-TK
A HIS 303 1.92 0.33 ABL1-TK
A ILE 304 0.73 0.20 ABL1-TK
A LEU 305 1.39 0.27 ABL1-TK
A ILE 328 0.91 0.05 ABL1-TK
B ARG 245 0.81 0.05 ABL1-TK

*Hot spot model based on shape specificity features; **Hot spot model based on biochemical features such as intermolecular hydrogen bonds.