Table 3: Association of SORL1 SNP rs11218343 with aMCI in ApoE ε4 stratified samples
N | Genotype n (%) | P | Allele n (%) | P | OR (95% CI) | ||||
CC | CT | TT | C | T | |||||
Total | |||||||||
aMCI | 63 | 9 (14.3) | 27 (42.9) | 27 (42.9) | 0.004 | 45 (34.3) | 81(65.7) | 0.005 | 1.870 (1.204-2.903) |
Control | 179 | 6 (3.35) | 70 (39.1) | 103 (57.5) | 82 (22.9) | 276 (77.1) | |||
ApoE ε4 (+) | |||||||||
aMCI | 12 | 3 (25.0) | 3 (25.0) | 6 (50.0) | 0.093 | 9 (35.7) | 15 (64.3) | 0.011 | 5.400 (1.438-20.273) |
Control | 20 | 1 (5.00) | 2 (10.0) | 17 (85.0) | 4 (10.0) | 36 (90.0) | |||
ApoE ε4 (-) | |||||||||
aMCI | 51 | 6 (11.8) | 23 (45.1) | 22 (43.1) | 0.040 | 35 (34.0) | 67 (66.0) | 0.052 | 1.607 (0.993-2.603) |
Control | 159 | 5 (3.14) | 68 (42.8) | 86 (54.1) | 78 (24.5) | 240 (75.5) |