Table 1: Morning versus evening administration of once-daily oral cardiovascular drugs.
Medications | Optimal dosing time | References | ||
Favoring evening dosing | Favoring morning dosing | Indifferent dosing time | ||
Perindopril | √ | [4] | ||
Ramipril | √ | [5] | ||
Candesartan | √ | [6,7] | ||
Olmesartan | √ | [8] | ||
√ | [9,10] | |||
Valsartan | √ | [11] | ||
√ | [12,13] | |||
Nebivolol | √ | [14] | ||
Nifedipine gastrointestinal therapeutic system | √ | [15,16] | ||
Amlodipine | √ | [17] | ||
Diuretics (thiazides, torasemide)a | √ | [19,20] | ||
Valsartan/hydrochlorothiazide | √ | [21] | ||
Indapamide/losartan | √ | [22] | ||
Amlodipine/hydrochlorothiazide | √ | [23] | ||
Amlodipine/valsartan | √ | [24,25] | ||
√ | [26] | |||
Amlodipine/olmesartan | √ | [27] | ||
√ | [28] | |||
Amlodipine/telmisartan | √ | [29] | ||
Amlodipine/fosinopril | √ | [30] | ||
Miscellaneous combination of antihypertensives | √ (Ingesting ≥ 1 antihypertensives) | [31-39] | ||
Cardiovascular polypills (aspirin, simvastatin, lisinopril, hydrochlorothiazide) | √ | [40] | ||
Simvastatin immediate-release | √ | [41] | ||
Controlled-release simvastatin | √ | [42,43] | ||
Ezetimibe/simvastatin | √ | [44] | ||
Rivaroxaban | √ | [45] | ||
Aspirin | √ | [46-48,51] | ||
√ | [49,50] |
Notes: aMorning dosing could still be used for patients with troublesome night-time diuresis with poor quality sleep; √: Given.