Table 4: Replicated results from gene-based analysis in GENOA N = 1,090.

Left ventricular traits Genename Gene-based association p-values
MAF < 1% MAF < 5%
Burden MB SKAT VT Burden MB SKAT VT
E/A ratio KCNH4 0.13

(++)

0.13

(++)

0.18

(++)

0.21

(++)

0.13

(++)

0.13

(++)

0.13

(++)

0.21

(++)

LAD ENDOG 0.39

(+)

0.39

(+)

0.39

(+)

0.39

(+)

0.39

(+)

0.39

(+)

0.39

(+)

0.39

(+)

LVIDD RAMP1 N/A N/A N/A N/A N/A N/A N/A N/A
E/A ratio PHKB 0.41

(++++--)

0.45

(++++--)

0.74

(++++-)

0.60

(+++--)

0.63

(+++++----)

0.55

(++++----)

0.86

(++++----)

0.64

(+++--)

LAD GPR55 0.68

(--)

0.57

(--)

0.28

(--)

0.21

(-)

0.71

(---)

0.91

(---)

0.54

(---)

0.30

(-)

LVM GPR55 0.98

(--)

0.99

(--)

0.99

(--)

0.99

(--)

0.03

(---)

0.15

(---)

0.02

(---)

0.08

(---)

E/A ratio GPR55 0.44

(--)

0.46

(--)

0.66

(--)

0.63

(-)

0.03

(---)

0.07

(---)

0.05

(---)

0.07

(---)

*The models were adjusted for age, gender, center, body mass index and first 10 principal components. Direction of SNPs contributing gene-based analysis inside parentheses. Plus means increase, minus means decrease compared to common alleles (additive model). E/A ratio: The ratio of left ventricular transmitral early velocity to late/atrial velocity; LAD: Left Atrial Dimension; LVIDD: Left Ventricular Internal Dimension-Diastole; LVM: Left Ventricular Mass; E/A ratio, LVIDD and LVM were natural log-transformed. LAD was square-rooted. MB: The Madsen-Browning Weighted Burden Test; SKAT: The Sequence Kernel Association Test; VT: The Variable Frequency Threshold Test; MAF: Minor Allele Frequency.