Table 4: Replicated results from gene-based analysis in GENOA N = 1,090.
Left ventricular traits | Genename | Gene-based association p-values | |||||||
---|---|---|---|---|---|---|---|---|---|
MAF < 1% | MAF < 5% | ||||||||
Burden | MB | SKAT | VT | Burden | MB | SKAT | VT | ||
E/A ratio | KCNH4 | 0.13 (++) |
0.13 (++) |
0.18 (++) |
0.21 (++) |
0.13 (++) |
0.13 (++) |
0.13 (++) |
0.21 (++) |
LAD | ENDOG | 0.39 (+) |
0.39 (+) |
0.39 (+) |
0.39 (+) |
0.39 (+) |
0.39 (+) |
0.39 (+) |
0.39 (+) |
LVIDD | RAMP1 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
E/A ratio | PHKB | 0.41 (++++--) |
0.45 (++++--) |
0.74 (++++-) |
0.60 (+++--) |
0.63 (+++++----) |
0.55 (++++----) |
0.86 (++++----) |
0.64 (+++--) |
LAD | GPR55 | 0.68 (--) |
0.57 (--) |
0.28 (--) |
0.21 (-) |
0.71 (---) |
0.91 (---) |
0.54 (---) |
0.30 (-) |
LVM | GPR55 | 0.98 (--) |
0.99 (--) |
0.99 (--) |
0.99 (--) |
0.03 (---) |
0.15 (---) |
0.02 (---) |
0.08 (---) |
E/A ratio | GPR55 | 0.44 (--) |
0.46 (--) |
0.66 (--) |
0.63 (-) |
0.03 (---) |
0.07 (---) |
0.05 (---) |
0.07 (---) |
*The models were adjusted for age, gender, center, body mass index and first 10 principal components. Direction of SNPs contributing gene-based analysis inside parentheses. Plus means increase, minus means decrease compared to common alleles (additive model). E/A ratio: The ratio of left ventricular transmitral early velocity to late/atrial velocity; LAD: Left Atrial Dimension; LVIDD: Left Ventricular Internal Dimension-Diastole; LVM: Left Ventricular Mass; E/A ratio, LVIDD and LVM were natural log-transformed. LAD was square-rooted. MB: The Madsen-Browning Weighted Burden Test; SKAT: The Sequence Kernel Association Test; VT: The Variable Frequency Threshold Test; MAF: Minor Allele Frequency.