Table 3: Patient demographics and disease characteristics by study drug†.
Study Drug |
|||||
Characteristics |
Metformin ER n= 995 |
Colesevelam n = 1639 |
Azilsartan n = 1364 |
Azilsartan/Chlorthalidone n = 498 |
Diltiazem ER n = 199 |
Age, Years |
58.2 ± 11.8 |
61.8 ± 11.5 |
57.3 ± 11.0 |
57.7 ± 9.9 |
67.0 ± 12.6 |
Height, cm |
168.1 ± 10.2 |
166.9 ± 14.1 |
168.8 ± 15.4 |
168.7 ± 9.8 |
168.3 ± 10.5 |
Weight, kg |
87.7 ± 21.2 |
81.9 ± 18.5 |
84.0 ± 20.0 |
87.5 ± 19.9 |
84.5 ± 17.9 |
Waist circumference, cm |
102.7 ± 21.2 |
94.4 ± 14.0 |
96.4 ± 16.7 |
101.1 ± 15.4 |
88.5 ± 12.4 |
BMI, kg/m2 |
31.3 ± 6.8 |
29.5 ± 6.2 |
29.8 ± 6.8 |
30.9 ± 6.2 |
29.7 ± 5.5 |
BMI Category, % |
|
|
|
|
|
< 27 |
26.6 |
37.2 |
33.7 |
29.1 |
31.2 |
27-30 |
18.0 |
22.5 |
21.8 |
18.5 |
27.6 |
> 30 |
46.1 |
38.0 |
36.8 |
45.8 |
39.7 |
Current smoker, % |
11.2 |
12.1 |
10.6 |
12.0 |
12.6 |
Previous smoker, % |
75.8 |
74.4 |
78.8 |
87.1 |
94.7 |
Duration in pack years |
151.5 ± 643.8 |
94.1 ± 210.4 |
128.2 ± 342.7 |
78.7 ± 185.0 |
78.3 ± 196.5 |
Male, % |
59.1 |
54.0 |
58.9 |
58.0 |
53.3 |
Race, % |
|
|
|
|
|
Caucasian |
55.3 |
51.1 |
44.9 |
47.4 |
74.9 |
Black |
4.6 |
7.6 |
6.1 |
10.6 |
2.5 |
Asian |
25.5 |
24.5 |
34.1 |
28.3 |
3.0 |
Hispanic |
1.2 |
1.7 |
1.1 |
1.4 |
0.0 |
Other |
6.0 |
8.0 |
5.0 |
5.4 |
1.5 |
Missing |
7.3 |
7.1 |
8.9 |
6.8 |
18.1 |
Disease duration, yrs |
4.9 ± 5.6 |
4.9 ± 6.7 |
4.7 ± 6.4 |
5.9 ± 6.4 |
9.5 ± 9.6 |
Vascular disorders, % |
53.9 |
54.7 |
1.5 |
1.2 |
3.1 |
Cardiac disorders, % |
5.7 |
9.7 |
4.3 |
4.2 |
12.3 |
SBP, mmHG‡ |
|
|
149.7 ± 14.7 |
153.3 ± 16.5 |
150.2 ± 15.0 |
DBP, mmHG‡ |
|
|
88.7 ± 9.8 |
89.4 ± 11.1 |
87.0 ± 8.3 |
Pulse, bpm‡ |
|
|
76.2 ± 9.6 |
75.1 ± 8.9 |
77.0 ± 11.2 |
eGFR, ml/min‡ |
|
|
84.3 ± 17.4 |
82.4 ± 16.5 |
78.1 ± 20.7 |
Serum Potassium, mmol/L‡ |
|
|
4.7 ± 5.4 |
5.4 ± 20.8 |
4.3 ± 0.4 |
LDL-C, mmol/L§ |
|
3.1 ± 1.1 |
|
|
|
HDL-C, mmol/L§ |
|
1.4 ± 2.0 |
|
|
|
Non HDL-C, mmol/L§ |
|
4.0 ± 1.4 |
|
|
|
TC, mmol/L§ |
|
5.3 ± 1.3 |
|
|
|
TG, mmol/L§ |
|
2.1 ± 1.6 |
|
|
|
A1C, %¶ |
7.5 ± 1.4 |
6.8 ± 1.5 |
|
|
|
ACR, mg/mmol/L |
16.0 ± 44.8 |
16.8 ± 33.0 |
16.9 ± 43.4 |
24.5 ± 51.7 |
3.7 ± 9.8 |
FPG, mmol/L¶ |
8.4 ± 2.9 |
7.0 ± 3.9 |
|
|
|
Mean ± standard deviation. Previous smoker, duration in pack years (number of cigarettes per day x number of years as a smoker). Note that patients may have taken more than one study drug and therefore maybe represented in more than one study drug group.
†Data based on the primary analysis population; ‡Reported for hypertension patients only; §Reported for hypercholesterolemia patients only; ¶A1C and FPG reported for hypercholesterolemia and type 2 diabetes patients only.