Table 3: Patient demographics and disease characteristics by study drug†.

 Study Drug

Characteristics

Metformin ER

n= 995

Colesevelam

n = 1639

Azilsartan

n = 1364

Azilsartan/Chlorthalidone

n = 498

Diltiazem ER

n = 199

Age, Years

58.2 ± 11.8

61.8 ± 11.5

57.3 ± 11.0

57.7 ± 9.9

67.0 ± 12.6

Height, cm

168.1 ± 10.2

166.9 ± 14.1

168.8 ± 15.4

168.7 ± 9.8

168.3 ± 10.5

Weight, kg

87.7 ± 21.2

81.9 ± 18.5

84.0 ± 20.0

87.5 ± 19.9

84.5 ± 17.9

Waist circumference, cm

102.7 ± 21.2

94.4 ± 14.0

96.4 ± 16.7

101.1 ± 15.4

88.5 ± 12.4

BMI, kg/m2

31.3 ± 6.8

29.5 ± 6.2

29.8 ± 6.8

30.9 ± 6.2

29.7 ± 5.5

BMI Category, %

 

 

 

 

 

< 27

26.6

37.2

33.7

29.1

31.2

27-30

18.0

22.5

21.8

18.5

27.6

> 30

46.1

38.0

36.8

45.8

39.7

Current smoker, %

11.2

12.1

10.6

12.0

12.6

Previous smoker, %

75.8

74.4

78.8

87.1

94.7

Duration in pack years

151.5 ± 643.8

94.1 ± 210.4

128.2 ± 342.7

78.7 ± 185.0

78.3 ± 196.5

Male, %

59.1

54.0

58.9

58.0

53.3

Race, %

 

 

 

 

 

Caucasian

55.3

51.1

44.9

47.4

74.9

Black

4.6

7.6

6.1

10.6

2.5

Asian

25.5

24.5

34.1

28.3

3.0

Hispanic

1.2

1.7

1.1

1.4

0.0

Other

6.0

8.0

5.0

5.4

1.5

Missing

7.3

7.1

8.9

6.8

18.1

Disease duration, yrs

4.9 ± 5.6

4.9 ± 6.7

4.7 ± 6.4

5.9 ± 6.4

9.5 ± 9.6

Vascular disorders, %

53.9

54.7

1.5

1.2

3.1

Cardiac disorders, %

5.7

9.7

4.3

4.2

12.3

SBP, mmHG

 

 

149.7 ± 14.7

153.3 ± 16.5

150.2 ± 15.0

DBP, mmHG

 

 

88.7 ± 9.8

89.4 ± 11.1

87.0 ± 8.3

Pulse, bpm

 

 

76.2 ± 9.6

75.1 ± 8.9

77.0 ± 11.2

eGFR, ml/min

 

 

84.3 ± 17.4

82.4 ± 16.5

78.1 ± 20.7

Serum Potassium, mmol/L

 

 

4.7 ± 5.4

5.4 ± 20.8

4.3 ± 0.4

LDL-C, mmol/L§

 

3.1 ± 1.1

 

 

 

HDL-C, mmol/L§

 

1.4 ± 2.0

 

 

 

Non HDL-C, mmol/L§

 

4.0 ± 1.4

 

 

 

TC, mmol/L§

 

5.3 ± 1.3

 

 

 

TG, mmol/L§

 

2.1 ± 1.6

 

 

 

A1C, %

7.5 ± 1.4

6.8 ± 1.5

 

 

 

ACR, mg/mmol/L

16.0 ± 44.8

16.8 ± 33.0

16.9 ± 43.4

24.5 ± 51.7

3.7 ± 9.8

FPG, mmol/L

8.4 ± 2.9

7.0 ± 3.9

 

 

 

Mean ± standard deviation. Previous smoker, duration in pack years (number of cigarettes per day x number of years as a smoker). Note that patients may have taken more than one study drug and therefore maybe represented in more than one study drug group.

Data based on the primary analysis population; Reported for hypertension patients only; §Reported for hypercholesterolemia patients only; A1C and FPG reported for hypercholesterolemia and type 2 diabetes patients only.