Table 1: Copper complexes with antimicrobial
activity.
|
Compound* |
Better
activity than ligand against (MIC) |
Ref. |
|
[Cu(2AcpClPh)Cl]∙2H2Oa |
S.
aureus (10 µM) and E. faecalis (122 µM) |
[15] |
|
[Cu(phen)(cnge)(H2O)(NO3)2]b |
E.
faecalis (24 µg mL-1) |
[16] |
|
[Cu(MeimzH)2(phen)(H2O)2]Cl2c |
E.
faecalis (81 µM) |
[17] |
|
[Cu(phen)2Cl]Clc |
P.
aeruginosa (365 µM) and E. faecalis
(23.4 µM) |
|
|
[Cu(L1)2]d |
P.
aeruginosa (n.p.) |
[18] |
|
[CuL2]Cl2e |
E.
coli (62.5 µg mL-1), S. aureus (125 µg mL-1),
L. monocytogenes (125 µg mL-1), S. typhimurium (125 µg
mL-1), P. aeruginosa (125 µg mL-1), C.
albicans (62.5 µg mL-1) and A. niger (125 µg mL-1) |
[19] |
|
[Cu(sulfisoxazole)2(H2O)4]∙2H2O |
S.
aureus (128 µg mL-1) and E. coli (128 µg
mL-1) |
[20] |
|
[Cu(sulfamethizole)2]∙H2O |
S.
aureus (32 µg mL-1) and E. coli (32 µg
mL-1) |
|
|
[Cu(sulfamethoxazole)2(H2O)4]∙3H2O |
S.
aureus (4 µg mL-1) and E. coli (32 µg mL-1) |
|
|
[Cu(sulfamethoxazole)2]∙H2O |
S.
aureus (16 µg mL-1) and E. coli (16 µg
mL-1) |
|
|
Cu(L3)2f |
S.
aureus (200 µg mL-1), E. coli (200 µg mL-1)
and P. aeruginosa (500 µg mL-1) |
[21] |
|
Cu(BHMQMHI)2g |
S.
aureus (25 µg mL-1), B. subtilis (50 µg mL-1),
P. aeruginosa (12,5 µg mL-1), A. flavus (75 µg mL-1),
A. niger (12.5 µg mL-1) and C. albicans (25
µg mL-1) |
[22] |
|
CuL4
h |
A.
niger (18 µg mL-1), A. flavus (19 µg mL-1),
R. stolonifer (22 µg mL-1), C. albicans (24 µg mL-1),
R. bataicola (27 µg mL-1) and T. harzianum (31
µg mL-1) |
[23] |
|
[Cu(L5)(Cip)(H2O)2]·3H2Oi |
M.
tuberculosis (9.28 µg mL-1) |
[24] |
|
[Cu(L6)(CQ)Cl]·3
H2O j |
S.
marcescens (1.7 µM), P. aeruginosa (2.6
µM) and E. coli (1.9 µM) |
[25] |
|
[Cu(L7)(CQ)Cl]·H2Ok |
S.
aureus (0.5 µM), B. subtilis (0.6 µM), S. marcescens (1.0
µM), P. aeruginosa (0.9 µM) and E. coli (0.7 µM) |
|
|
[Cu(L8)(CQ)Cl]·2
H2Ok |
S.
aureus (0.65 µM), B. subtilis (0.7 µM), S. marcescens (1.25
µM), P. aeruginosa (1.1 µM) and E. coli (0.9 µM) |
|
|
[Cu(methoxysalicylaldehyde-tryptophan)2] |
B.
subtilis (n.p.), E. coli (n.p.), M. luteus (n.p.),
A. niger (n.p.) and S. cerevisiae (n.p.) |
[26] |
|
[Cu(diethylaminosalicylaldehyde-phenylalanine)2] |
B.
subtilis (n.p.), E. coli (n.p.), M. luteus (n.p.),
A. niger (n.p.) and S. cerevisiae (n.p.) |
|
|
[Cu(diethylaminosalicylaldehyde-histidine)2] |
B.
subtilis (n.p.), E. coli (n.p.), M. luteus (n.p.),
A. niger (n.p.) and S. cerevisiae (n.p.) |
|
|
[Cu(L9)(µ1-1-N3)]2l |
E.
faecalis (78 µg mL-1), S. aureus (78 µg mL-1),
E. aerogenes (156 µg mL-1), E. coli (156 µg mL-1),
K. pneumoniae(156 µg mL-1) and P. mirabilis (156
µg mL-1) |
[27] |
|
[Cu(L9)(NCS)(MeOH)]l |
E.
faecalis (625 µg mL-1), S. aureus (625 µg mL-1),
E. aerogenes (625 µg mL-1), E. coli (625 µg mL-1),
K. pneumoniae (625 µg mL-1) and P. mirabilis (625
µg mL-1) |
|
|
[Cu(L10)(phen)]m |
E.
coli (78 µg mL-1), S. aureus (62.5 µg mL-1),
P. aeruginosa (125 µg mL-1), L. monocytogenes (62.5 µg
mL-1) and C. albicans (39 µg mL-1) |
[28] |
|
[Cu(L11)(NO3)(
H2O)2]n |
S.
aureus (n.p.), Enterococcus sp. (n.p.) and C. albicans (n.p.) |
[29] |
|
[Cu(L11)2ClO4(
H2O)]n |
E.
coli (n.p.), S. aureus (n.p.), Enterococcus sp. (n.p.)
and C. albicans (n.p.) |
|
|
[Cu(AMTT)]nClno |
E.
coli (n.p.), S. aureus (n.p.) and P.
aeruginosa (n.p.) |
[30] |
a2AcpClPh:
2-acetylpyridine-para-chloro-phenylhidrazone
bcnge: cyanoguanidine and phen:
ortho-phenantroline
cMeimzH: methimazole and phe:
phenantroline
dL1:
N-4-fluorobenzoylpiperidine-1-carbothioimidate
eL2: (E)-N-(furan-2-yl
methylene)quinolin-8-amine
f(HL3):
4-((5-Nitrofuran-2-yl)methyleneamino)- 5-mercapto-1,2,4-triazole
gBHMQMHI: 5-Bromo-3-(((8-hydroxy-2-methylquinoline-7yl)
methylene) hydrazono) indolin-2-one
hH2L4:
Acetoacetanilido-4-aminoantipyrinyl-2-aminobenzoic acid
iL5:
7-hydroxy-10,11-dihydroindeno[5,4-c]chromen-6(9H)-one; CQ: clioquinol; Cipro:
ciprofloxacin
jL6:
4´-(4-bromophenyl)-2,2´: 6,2´ ´-terpyridine; L7:
4´-(4-fluorophenyl)-2,2´:6´,2´ ´–terpyridine; L8: 4´-(4-methoxyphenyl)-2,2´:6´,2´ ´-terpyridine
kL7:
4'-(4-fluorophenyl)-2,2':6',2''-terpyridine
lL9: pyridine 2-carbaldehyde 4-hydroxy
benzoyl hidrazone, N3-: azide; SCN-: thyocianate.
mL10: (E)-N´-(2-hydroxybenzylidene)
acetohydrazide
nL11: ethyl
4-[(E)-(2-hydroxy-4-methoxyphenyl)methyleneamino] benzoate
oAMTT:
4-amino-5-methyl-2H-1,2,4-triazole-3(4H)-thione
*All
the chemical names were in accordance to bibliographic references
n.p: MIC not
published