Table 1: Timeline of Staphylococcus aureus antibiotic resistance [11].
Antibiotic | Year Antibiotic Introduced | Year Resistance Identified | Notes |
Penicillin | 1943 | 1940 | Penicillinase, a highly potent plasmid-encoded β-lactam ring hydrolyzer, was extracted from naturally resistant strains of S. aureus samples, collected before its clinical use |
Methicillin | 1960 | 1962 | Before widespread use, resistance to Celbenin (Methicillin) was noted in clinical isolates obtained from skin lesions and anterior nares of hospitalized patients with no previous exposure to the drug. |
Linezolid | 2000 | 2001 | |
Vancomycin | 1972 | 2002 | Resistance development evolved slowly over time with MIC creeps, therapeutic failures, VISA then VRSA |
Ceftaroline | 2010 | 2011 |