Table 1: Timeline of Staphylococcus aureus antibiotic resistance .
|Antibiotic||Year Antibiotic Introduced||Year Resistance Identified||Notes|
|Penicillin||1943||1940||Penicillinase, a highly potent plasmid-encoded β-lactam ring hydrolyzer, was extracted from naturally resistant strains of S. aureus samples, collected before its clinical use|
|Methicillin||1960||1962||Before widespread use, resistance to Celbenin (Methicillin) was noted in clinical isolates obtained from skin lesions and anterior nares of hospitalized patients with no previous exposure to the drug.|
|Vancomycin||1972||2002||Resistance development evolved slowly over time with MIC creeps, therapeutic failures, VISA then VRSA|