Table 3d: Cephalosporins
Ceftaroline | 2010 |
• Fifth-generation cephalosporin with extended Gram-positive activity. • Only FDA approved cephalosporin with activity against VISA, VRSA and linezolid- and daptomycin-resistant S. aureus [49]. • Approved for the treatment of acute bacterial SSSIs and community-acquired pneumonia. • Demonstrates excellent affinity for prominent PBPs that are used by resistant strains [49-50]. • Synergy with carbapenems, azactams and some aminoglycosides. • Low probability of developing resistance. • Favorable safety and tolerability profile. |