Table 3: Factors associated with viral un-suppression among HIV infected patients referred for HIV viral load testing at Amhara Public Health Institute Dessie Branch Regional Reference laboratory from January 1/2017 to January 1/2019. (N = 32,778)
|
Variables |
Viral Suppression Status |
COR (95% CI) |
AOR (95% CI) |
P - Value
|
|
|
Categories |
Suppressed n (%) |
Unsuppressed n (%) |
|||
|
Gender |
|
|
|
|
|
|
Female |
17927 (86.1) |
2892 (13.9) |
1 |
- |
- |
|
Male |
9906 (82.8) |
2053 (17.2) |
1.285 (1.208-1.366) |
1.300 (1.213-1.392) |
< 0.001 |
|
Age |
|
|
|
|
|
|
1-4 |
45 (50) |
45 (50) |
6.208 (4.070-9.469) |
8.526 (8.476-13.276) |
< 0.001 |
|
5-9 |
325 (61) |
208 (39) |
3.973 (3.271-4.826) |
5.530 (4.489-6.812 |
< 0.001 |
|
10-14 |
740 (64.3) |
410 (35.7) |
3.440 (2.965-3.991) |
5.024 (4.267-5.916) |
< 0.001 |
|
15-19 |
584 (65.2) |
312 (34.8) |
3.317 (2.820-3.902) |
4.810 (4.024-5.750) |
< 0.001 |
|
20-24 |
1059 (81) |
248 (19) |
1.454 (1.235-1.712) |
2.177 (1.823-2.600) |
< 0.001 |
|
25-29 |
3614 (86.5) |
562 (13.5) |
0.965 (0.853-1.093) |
1.422 (1.236-1.636) |
< 0.001 |
|
30-34 |
5349 (86.3) |
847 (13.7) |
0.983 (0.878-1.101) |
1.478 (1.299-1.682) |
< 0.001 |
|
35-39 |
5566 (87.6) |
785 (12.4) |
0.876 (0.781-0.982) |
1.273 (1.118-1.451) |
< 0.001 |
|
40-44 |
4185 (87.9) |
575 (12.1) |
0.853 (0.754-0.965) |
1.124 (0.977-1.292) |
0.101 |
|
45-49 |
2672 (88.2) |
358 (11.8) |
0.832 (0.723-0.957) |
1.013 (0.864-1.188) |
0.869 |
|
> 50 |
3694 (86.1) |
595 (13.9) |
1 |
- |
- |
|
Region |
|
|
|
|
|
|
Afar |
92 (86.8) |
14 (13.2 |
1.168 (0.665-2.051) |
- |
- |
|
Amhara |
27741 (84.9) |
4931(15.1) |
1 |
- |
- |
|
Test Reason |
|
|
|
|
|
|
Routine VL |
13157 (89.9 |
1481 (10.1) |
1 |
1 |
|
|
First VL |
14568 (82.1) |
3169 (17.9) |
1.933 (1.809-2.064) |
1.936 (1.805-2.077) |
< 0.001 |
|
Targeted repeat VL |
108 (26.8) |
295 (73.2 |
24.266 (19.340-30.446) |
23.131 (18.249-29.318) |
< 0.001 |
|
WHO Stage |
|
|
|
|
|
|
Stage I |
26645 (86.7) |
4084 (13.3) |
1 |
1 |
|
|
Stage II |
11.03 (73.8) |
391 (26.2) |
2.313 (2.051-2.608) |
2.544 (2.238-2.891) |
< 0.001 |
|
Stage III |
61 (18.2) |
274 (81.8) |
29.306 (22.161-38.753) |
37.454 (28.113-49.899) |
< 0.001 |
|
Stage IV |
24 (10.9) |
196 (89.1) |
53.281 (34.829-81.510) |
75.352 (48.831-116.277) |
< 0.001 |
|
Adherence |
|
|
|
|
|
|
Good |
27812 (85) |
4913 (15) |
1 |
1 |
|
|
Fair |
19 (39.6) |
29 (60.4) |
8.640 (8.841-15.421) |
6.838 (3.516-13.299) |
< 0.001 |
|
Poor |
2 (40) |
3 (60) |
8.491 (1.418-50.831) |
2.986 (0.343-26.001) |
0.322 |
|
Pregnancy Status |
|
|
|
|
|
|
Yes |
223 (90.7) |
23 (9.3) |
1.728 (1.124-2.658) |
0.752 (0.485-1.168) |
0.205 |
|
No |
17704 (86.1) |
2869 (13.9) |
1 |
1 |
|
|
Breastfeeding Status |
|
|
|
|
|
|
Yes |
168 (81.6) |
38 (18.4) |
0.784 (0.551-1.117) |
1.628 (1.119-2.368) |
0.011 |
|
No |
17759 (86.2) |
2854 (13.8) |
1 |
1 |
|
COR: Crude Odds Ratio; AOR: Adjusted Odds Ratio; CI: Confidence Interval