Table 1: Fold Change expression (relative to UI) of Wound Healing genes after injection of TGF-β1.
| Gene‡ | Fold Change‡‡ | p# | ||
| 3 d | 9 d | 28 d | ||
| ECM Structure | ||||
| Col14a1 | - | 12.6 | 4.4 | ** |
| Col1a1 | - | 10.7 | 3 | * |
| Col1a2 | -2.4 | 2.2 | - | |
| Col3a1 | 3.5 | 6.1 | - | |
| Col4a1 | - | 2.7 | - | |
| Col4a3 | -4.5 | -1.7 | - | |
| Col5a1 | 5.6 | 10.1 | - | |
| Col5a2 | 4.4 | 7.8 | - | |
| Col5a3 | 4 | 3 | - | |
| ECM Remodeling enzymes | ||||
| Ctsk | -2.2 | 7.1 | 3.8 | *** |
| Ctsl | - | 2.1 | 1.6 | |
| Mmp2 | - | 11.7 | 6 | ** |
| Mmp9 | 9.7 | 10.4 | - | |
| Plat | 3 | 4.6 | 1.5 | |
| Plau | 4.2 | 2.6 | - | |
| Plaur | -4 | 6.7 | 1.6 | |
| Plg | 4.2 | -1.6 | - | |
| Serpine1 | 108.1 | 10.7 | 1.9 | |
| Timp1 | 13.3 | 9.3 | 2.7 | |
| Cell Adhesion molecules | ||||
| Cdh1 | 66.5 | 35.4 | 6.1 | ** |
| Itga1 | -2.3 | - | - | |
| Itga2 | -4 | - | - | |
| Itga3 | - | 1.9 | - | |
| Itga4 | 2 | 2 | - | |
| Itga5 | 6.8 | 4.4 | 1.7 | |
| Itga6 | - | - | - | |
| Itgav | 2.3 | 2.1 | 1.5 | |
| Itgb1 | 2 | 3.1 | 1.9 | *** |
| Itgb3 | - | 2 | 1.6 | |
| Itgb5 | - | 1.7 | 1.6 | ** |
| Itgb6 | -11.6 | -2.6 | - | |
| Cytoskeleton | ||||
| Acta2 | 1.5 | |||
| Actc1 | -12.9 | -1.5 | -2 | |
| Rac1 | -1.4 | - | - | |
| Rhoa | 1.2 | 2.1 | - | |
| Tagln | -2 | - | - | |
| Growth factors & cytokines | ||||
| Angpt1 | -1.7 | 2.7 | 2.1 | * |
| Ccl12 | - | 2.5 | - | |
| Ccl7 | 14.5 | 2.7 | - | |
| Cd40lg | -3.1 | 2 | -2 | |
| Csf2 | - | 2.5 | 1.8 | |
| Csf3 | - | -1.7 | - | |
| Ctgf | -1.6 | -1.5 | 1.8 | |
| Ctnnb1 | 1.9 | 4.1 | 2.1 | |
| Cxcl11 | -12.7 | -2.2 | -2 | |
| Cxcl5 | 510.2 | 16.3 | -3.8 | |
| Egf | -2.6 | 1.7 | - | |
| Egfr | - | 2.6 | - | |
| Fgf10 | -11 | -4 | -2.8 | * |
| Fgf2 | - | 1.7 | 1.7 | |
| Fgf7 | -1.7 | -1.3 | 1.5 | |
| Hbegf | 6.7 | 3.3 | - | ** |
| Hgf | 7.1 | 6.9 | 3.3 | |
| Igf1 | - | 7.6 | - | |
| Il10 | 2.2 | 6.6 | - | * |
| Il6st | -1.1 | 1.6 | 2.4 | |
| Mapk1 | - | 1.7 | 1.8 | |
| Mapk3 | - | 3 | 3.1 | * |
| Mif | 3.5 | 2.8 | - | |
| Pdgfa | - | 2.1 | - | |
| Pten | - | 1.9 | - | |
| Stat3 | 2.6 | 3.8 | 1.6 | |
| Tgfb1 | 2.7 | 2.7 | 1.6 | |
| Tgfbr3 | -1.8 | 1.9 | ||
| Tnf | 6 | 7.2 | 1.5 | |
| Vegfa | - | - | -1.6 | |
| Wisp1 | 8.7 | 7.8 | - | |
‡Genes are organized in functional groups.
A complete listing of all genes on the array plates is shown in Supplementary Table 2 and mRNA abundance values for each gene in the UI tendons is shown in Supplementary Table 4.
‡‡3 replicate tissue pools were analyzed for UI and 28 d groups and duplicate pools for 3 d and 9 d groups (see Table 1 for details).
#Statistical analyses was performed for comparison of UI and 28 d groups, with p values(*) = 0.05, (**) = 0.01, (***) = 0.001, (****) = 0.0001.
Genes for which expression was unaffected relative UI samples are marked with (-).