Table 2: Fold Change expression (relative to UI) of Nfkb Target genes after injection of TGF-β1.
Gene‡ | Fold Change‡‡ | p# | ||
3 d | 9 d | 28 d | ||
Cytokines & Chemokines | ||||
Ccl12 | - | 4 | - | |
Ccl22 | -4.6 | 3.2 | - | |
Ccl5 | - | 18 | - | |
Csf3 | - | 3.6 | - | |
Cxcl1 | 28 | 15.9 | 2.5 | |
Cxcl10 | 3.1 | 8.6 | - | |
Cxcl3 | 136.7 | 7.5 | 4.6 | |
Cxcl9 | -1.8 | 3.9 | - | |
Ifng | - | 3.1 | - | |
Il12b | - | 13.7 | 2.2 | |
Il15 | -5.4 | 2.2 | - | *** |
Il1b | 108.1 | 42.9 | 17.4 | |
Il1rn | 4.3 | 9.7 | - | |
Il4 | -5.5 | -5.9 | -3.2 | *** |
Il6 | 141.9 | 42.8 | 1.8 | |
Lta | -2.5 | - | -2.8 | ** |
Ltb | - | 2.5 | - | |
Tnfsf10 | -42.4 | - | - | |
Ccr5 | 4.9 | 5.9 | - | |
Il1r2 | 17.3 | - | -2 | |
Il2ra | -19.2 | - | - | |
Acute inflammation | ||||
C4a | - | 5.7 | 5.2 | **** |
F3 | -7 | -2.4 | - | |
F8 | -2.6 | 3.9 | - | |
Stat3 | - | 2 | - | |
Agt | -10 | - | - | |
Myd88 | 17 | 7 | 2.5 | ** |
Ptgs2 | 492.3 | 92.3 | 10.7 | ** |
Sele | - | 2 | - | |
Tnfrsf1b | 6.4 | 2.7 | 2.3 | |
Type I Interferon Responsive | ||||
Cd80 | - | 2.1 | - | |
Cdkn1a | -1.9 | 2.4 | - | |
Cfb | -2.8 | 1.8 | - | |
Ncoa3 | -8.2 | - | - | |
Irf1 | -2.2 | - | - | |
NFκB Signaling | ||||
Nfkb1 | -2 | - | - | |
Nfkb1 | -2 | - | - | |
Nfkb2 | - | 2.5 | 2.6 | **** |
Relb | 2.3 | 4.6 | - | |
Cd40 | 2.1 | 2.8 | - | |
Rel | 11 | 4.9 | - | |
Transcription factors | ||||
Egr2 | - | 4.1 | - | |
Myc | 2.6 | - | ||
Trp53 | - | 3.7 | - | |
Stat5b | -2.1 | - | - | |
Anti-Apoptotic | - | - | ||
Akt1 | 2.9 | |||
Bcl2a1a | - | 5.3 | - | |
Birc3 | - | 4 | 3.9 | ** |
Fas | -6 | - | - | |
Sod2 | -5.1 | -1.9 | - | |
Xiap | -3.5 | - | - | |
Apoptosis | ||||
Birc2 | -3.9 | - | - | |
Cd74 | - | 2 | 2 | ** |
Egfr | -2.8 | 3.1 | ||
Fasl | 4.8 | - | 2.6 | |
Map2k6 | -10.8 | - | - | |
Mitf | -19 | - | - | |
Mmp9 | 3.5 | 7.2 | - | |
Nqo1 | -26.1 | - | - | |
Nr4a2 | 18.6 | 18.3 | 8.6 | *** |
Vcam1 | - | 13.8 | 5.8 | ** |
Stress Responses | ||||
Ccnd1 | - | 2.9 | - | |
Plau | 8.4 | - | - | |
Other Immune Response | ||||
Cd83 | - | 7.4 | 3.2 | * |
‡Genes are organized in functional groups.
A complete listing of all genes on the array plates is shown in Supplementary Table 3 and mRNA abundance values for each gene in the UI tendons is shown in Supplementary Table 4.
‡3 replicate tissue pools were analyzed for UI and 28 d groups and duplicate pools for 3 d and 9 d groups (see Table 1 for details).
#Statistical analyses was performed for comparison of UI and 28 d groups, with p values (*) = 0.05, (**) = 0.01, (***) = 0.001, (****) = 0.0001.
Genes for which expression was unaffected relative UI samples are marked with (-).