Fold Change expression in Wound Healing and Nfkb Target Genes following Oral E-IBU and L-IBU dosing.

Table 3: Fold Change expression in Wound Healing and Nfkb Target Genes following Oral E-IBU and L-IBU dosing.

	Wound Healing		Nfkb Targets
	Fold Change^#		Fold Change^#
Gene^‡	E-IBU	L-IBU	Gene^‡	E-IBU	L-IBU
Cxcl5	28.4^*	3.49^*	Il6	7.84^*	3.17
Col3a1	10.02^*	2.27^*	Il1rn	6.81^*	3.92^*
Mmp9	7.34^*	45.01^*	Cxcl3	6.11^*	2.56
Col5a1	6.9^*	4.32^*	Ptgs2	5.95^*	4.07^*
Wisp1	5.69^*	1.45	Ccl5	5.84^*	3.41^*
Col1a1	5.16^*	1.39	Cxcl10	5.58^*	2.73^*
Col5a2	4.99^*	3.68^*	Relb	4.33^*	2.35
Serpine1	4.72^*	1.66	F8	4.1^*	1.69
Timp1	3.91^*	1.29	Rel	4.09^*	2.01
Col1a2	3.83^*	1.07	Cxcl9	3.78^*	1.32
Col5a3	3.44^*	1.66	Lta	3.46^*	3.54
Cdh1	3.37^*	-1.31	Il12b	3.26^*	2^*
Plat	3.19^*	1.58	Ltb	3.23^*	2.08
Ccl12	3.17^*	1.15	Ccr5	3.2^*	2.92^*
Hgf	3.05^*	1.44	Ccl12	2.92^*	1.76
Itga4	3.01^*	1.11	Bcl2a1a	2.83^*	1.53
Stat3	2.75^*	2.27	Cdkn1a	2.46^*	1.8
Itga5	2.61^*	1.16	Ccl22	2.34^*	-1.09
Vegfa	2.49^*	1.99	Selp	2.27^*	2.98^*
Ctsk	2.47^*	1.8	Tnf	2.21^*	1.32
Mif	2.22^*	1.53	Rela	2.07^*	1.98^*
Col4a1	1.96^*	1.27	Sele	2.06^*	1.54
Rhoa	1.62^*	1.65^*	Gadd45b	1.98^*	1.21
Cd40lg	1.11	3.99^*	Cd80	1.84^*	1.59^*
Plg	-3.80^*	-1.98	Il1b	1.76^*	-2.7
			Nfkbia	1.64^*	1.51^*
			Ifng	1.11	2.47
			Csf3	1.07	4.25^*

^‡Genes are organized from highest to lowest fold activation; ^#Statistical analyses was performed for comparison with 25 d No Drug groups and ^* indicates p < 0.05.