Item assessed

Response

Score

Was the study described as randomized?

Yes

+1

No

0

Was the method of randomization appropriate?

Yes

+1

No

-1

Not described

0

Was the study described as blinded?^*

Yes

+1

No

0

Was the method of blinding appropriate?

Yes

+1

No

-1

Not described

0

Was there a description of withdrawals and dropouts?

Yes

+1

No

0

Was there a clear description of the inclusion/exclusion criteria?

Yes

+1

No

0

Was the method used to assess adverse effects described?

Yes

+1

No

0

Was the method of statistical analysis described?

Yes

+1

No

0

^*Double-blind received 1 score; single-blind received 0.5 score.