Growth Factor

Function

PDGF

Stimulates cell proliferation, chemotaxis, and differentiation; stimulates angiogenesis

TGF-Beta

Stimulates collagen type I and type III production, angiogenesis, re-epithelialization, and synthesis of protease inhibitors to inhibit collagen breakdown

VEGF

Regulates endothelial cell proliferation and migration

EGF

Modulates cell proliferation and cytoprotection, accelerates re-epithelialization, increases tensile strength in wounds, facilitates organization of granulation tissue

FGF

Stimulates angiogenesis, promotes stem cell differentiation and cell proliferation, promotes collagen production and tissue repair

IGF-1

Modulates cell proliferation and differentiation, influences matrix secretion from osteoblasts and production of proteoglycan, collagen, and other non-collagen proteins