Table 2: Probable relationship of the proposed diet and mechanism of arsenic poisoning.
Arsenic poisoning |
Mechanism |
Diet factors |
Counter mechanism |
Oxidative stress |
Oxidation reaction |
Green tea, pointed gourd fruit, gooseberry fruit, Vitamin C, turmeric, Amaranthus leaves, E. alba leaves |
Antioxidant |
DNA damage |
Dimethyl arsine peroxyl radical generation |
Turmeric, skunkvine leaves, Amaranthus leaves, E. alba leaves |
DNA repair |
Keratosis |
Over expression of epidermal keratinocytes |
Vitamin B12, Vitamin C, turmeric, ginger, Amaranthus leaves, E. alba leaves |
Chelation, DNA repair |
Liver damage |
Interaction with protein targets in hepatocytes |
E. alba leaves, Moringa leaves, garlic, corn fruit, papaya fruit, pointed gourd fruit |
Antioxidant, DNA repair |
Kidney damage, albuminurea, proteinurea |
Endothelial dysfunction |
Moringa leaves, Amaranthus leaves, garlic, corn fruit, pointed gourd fruit |
Antioxidant, DNA repair |
Skin cancer, liver cancer |
Unregulated proliferation (suppression of p53 pathway) |
Turmeric, ginger, green tea, cumin seeds, E. alba leaves |
Anticancer, antitumor, anti-inflammatory |
Cardiovascular diseases, Atherosclerosis |
Elevation of cell adhesion molecules, Oxidized lipids formation |
Garlic, ginger, Moringa leaves, green tea, skunkvine leaves |
Antioxidant, DNA repair |
Alzheimer’s, Parkinson’s disease |
Dopamine quinone radicals formation |
Turmeric, ginger, Moringa leaves |
Antioxidant, DNA repair |
Multiple organ failure |
Necrotic cell death |
Turmeric, ginger, green tea, Moringa leaves |
Antioxidant, Anti-inflammatory |