Table 3: The validation of fucoxanthinol and fucoxanthin in serum sample analyses.

	Fucoxanthinol	Fucoxanthin
Precision (%CV)	9.2	19.2
Recovery (%)	136.6	117.3
LOD (pg on column)	71.1	36.2
LLOQ (pg on column)	234.6	119.5
LOD as serum sample^*	0.58 nM	0.27 nM
LLOQ as serum sample^*	1.91 nM	0.91 nM

LOD: the Limit of Detection, LLOQ: the Lower Limit of Quantification

^*Following the developed protocol in current study.