Anti-cancer effects of individual food components and natural compounds combined in Nutrient Synergy.

Table 2: Anti-cancer effects of individual food components and natural compounds combined in Nutrient Synergy.

Process in Cancer	Beneficial effects/mechanisms
Oxidative stress	Scavenging free radicals
	Reduced oxidative stress^*
	Prevent DNA damage
	Inhibition of nitration and nitrosation
	Inhibition of Xanthine oxidase
Cancer cell growth and survival	Inhibition of cell proliferation^*
	Inhibition of cell differentiation
	Cell-cycle arrest^*
	Induction of apoptosis^*
Tumor growth and metastasis	Inhibition of angiogenesis^*
	Inhibition of cancer cells adhesion and invasion^*
	Inhibition of proteolytic destruction of connective tissue (MMPs, uPA)^*
	Increased synthesis of proteolysis inhibitors TIMP 1 and 2, PAI1^*
	Tumor encapsulation^*
Genetic	Inhibition of oncogene expression^*
	Induction of tumor suppressor genes^*
	DNA repair
Initiation/prevention	Support of detoxification process:
	Induction of Phase II enzymes, Glutathione peroxidase, Catalase, SOD
	Inhibition Phase I enzymes (blocking activation of carcinogens)
Support systems	Immune system enhancement
Support systems	Anti-inflammatory effects (inhibition of COX2, inducible iNOS)*
Metabolic effects	Steroid hormone metabolism regulation
	Modulation of glutamate metabolism
	Modulation of glycolytic and epithelial mesenchymal transition (EMT) genes expression*

^*Experimentally confirmed anti-cancer effects of Nutrient Synergy.