Table 4: Characteristics of experimental studies.

Author, year

Animal, genetic line, sex

Obesity model

Total n

Follow-up (days)

Interventions

Evaluated

variables

Delivery vehicle

Dosage given to the intervention group

Sasaki, et al. (2019) [32]

Mice, C57BL/6J, male

HFD

46

140

Mixed with food

2% of the total HFD

*

Rocha, et al. (2015) [33]

Rats, Wistar, male

Cafeteria diet

40

84

Oral gavage

500 mg/kg/day

Total body weight, body fat mass, serum TNF, IL-6, IL-1β, TC, TG, HDL, LDL, FFA

Santana, et al. (2015) [34]

Rats, Swiss, male

HFD

26

56

Oral gavage

50 mg/kg/day

Total body weight, body fat mass, liver TNF, serum glucose, insulin, HOMA-IR, TC, TG, HDL, LDL, FFA

Lu, et al. (2012) [35]

Rats, Sprague-Dawley, female

HFD

24

224

Dissolved in drinking water

0.5% (wt/vol)

Total body weight, serum IL-6, IL-1β

Shen, et al. (2015) [36]

Rats, Sprague-Dawley, female

HFD

48

224

Dissolved in drinking water

0.5% (wt/vol)

Total body weight, body fat mass, body free-fat mass

HFD: High Fat Diet; BMI: Body Mass Index; T2DM: Type 2 Diabetes Mellitus; CV: Cardiovascular Disease; TNF: Tumor Necrosis Factor; IL-6: Interleukin 6; CRP: C-reactive Protein; HOMA-IR: Homeostatic Model Assessment for Insulin Resistance; HbA1c: Glycated Hemoglobin; TC: Total Cholesterol; TG: Triglycerides; HDL: High-Density Lipoprotein Cholesterol; LDL: Low-Density Lipoprotein Cholesterol; FFA: Free Fatty Acids; BP: Blood Pressure. *Data not shown because evaluated variables by the authors were related to inflammation observed in nonalcoholic steatohepatitis, therefore not meeting the main parameters used in the results of our study. Still, specific results such as this study’s, were used to elaborate the discussion topic.