Table 4: Characteristics of experimental studies.
Author, year |
Animal, genetic line, sex |
Obesity model |
Total n |
Follow-up (days) |
Interventions |
Evaluated variables |
|
Delivery vehicle |
Dosage given to the intervention group |
||||||
Sasaki, et al. (2019) [32] |
Mice, C57BL/6J, male |
HFD |
46 |
140 |
Mixed with food |
2% of the total HFD |
* |
Rocha, et al. (2015) [33] |
Rats, Wistar, male |
Cafeteria diet |
40 |
84 |
Oral gavage |
500 mg/kg/day |
Total body weight, body fat mass, serum TNF, IL-6, IL-1β, TC, TG, HDL, LDL, FFA |
Santana, et al. (2015) [34] |
Rats, Swiss, male |
HFD |
26 |
56 |
Oral gavage |
50 mg/kg/day |
Total body weight, body fat mass, liver TNF, serum glucose, insulin, HOMA-IR, TC, TG, HDL, LDL, FFA |
Lu, et al. (2012) [35] |
Rats, Sprague-Dawley, female |
HFD |
24 |
224 |
Dissolved in drinking water |
0.5% (wt/vol) |
Total body weight, serum IL-6, IL-1β |
Shen, et al. (2015) [36] |
Rats, Sprague-Dawley, female |
HFD |
48 |
224 |
Dissolved in drinking water |
0.5% (wt/vol) |
Total body weight, body fat mass, body free-fat mass |
HFD: High Fat Diet; BMI: Body Mass Index; T2DM: Type 2 Diabetes Mellitus; CV: Cardiovascular Disease; TNF: Tumor Necrosis Factor; IL-6: Interleukin 6; CRP: C-reactive Protein; HOMA-IR: Homeostatic Model Assessment for Insulin Resistance; HbA1c: Glycated Hemoglobin; TC: Total Cholesterol; TG: Triglycerides; HDL: High-Density Lipoprotein Cholesterol; LDL: Low-Density Lipoprotein Cholesterol; FFA: Free Fatty Acids; BP: Blood Pressure. *Data not shown because evaluated variables by the authors were related to inflammation observed in nonalcoholic steatohepatitis, therefore not meeting the main parameters used in the results of our study. Still, specific results such as this study’s, were used to elaborate the discussion topic.