Table
1: Comparison of
reported MDNC of larynx with or without elevated serum calcitonin.
|
Authors year |
MDNC of larynx discussed in
study/case |
Age/sex |
Presentation |
Tumor Location |
Immunohistochemistry |
Serum calcitonin |
Thyroid specimen diagnosis |
|
Sweeney
et al. 1981 [6] |
01 |
54
years/M |
Hoarseness |
Left
arytenoid and 3 cervical lymph nodes |
Calcitonin+,
CEA+ |
1200 ng/L (ref. < 200) |
MTC - |
|
Woodruff
et al. 1985 [10] |
09 |
50 to 77
years (mean 63)/5 F,4 M |
Sore
throat, hoarseness, neck mass, dysphagia, regurgitation, weight loss,
dyspnea, throat discomfort |
Epiglottis,
right arytenoids area, intrinsic larynx bilaterally to sub glottis, extrusion
to cricoids cartilage, right false cord, left
arytenoids area, sub glottis area, right aryepiglottis |
Calcitonin+
(06 cases), CEA+ (04 cases), Somatostatin+ (02 cases), Serotonin+ (02 cases), HCG+ (01
cases), NSE+ (09 cases) |
Serum
calcitonin was higher in 06 cases |
- |
|
Smets et al. 1990 [8] |
01 |
55
years/M |
Hoarseness
and dysphagia |
laryngeal
surface of epiglottis and 3 submandibular lymph nodes |
Calcitonin+,
Chromogranin A+, CEA+, Cytokeratin+, NSE+, Somatostatin+ |
3790 pg/mL (ref. < 100) |
MTC - |
|
El-naggar et al. 1991 [11] |
01 |
42
years/F |
no signs
or symptoms suggestive of a carcinoid syndrome/neuroendocrine tumours |
Polypolid laryngeal adenocarcinoma glottic in origin, cervical metastasis to 1 lymph node |
Somatostatin -, Serotonin +, ACTH -, Neuron
specific enolase +, Chromogranin
+, CEA+, Calcitonin+ |
Calcitonin
level was normal |
No
thyroid abnormality |
|
Insabato et al. 1993 [9] |
01 |
69
years/M |
Hoarseness |
Right
arytenoid, 1 cervical lymph node |
Calcitonin+,
Chromogranin A+, NSE+, Cytokeratin+, |
970 pg/mL (ref. < 300) |
MTC -,
Diffuse goiter |
|
Labryer et al. 2015 [2] |
01 |
57
years/M |
Right-sided
otalgia, odynophagia, and hoarseness |
Right
medial arytenoid lesion (1 cm) in size, mucosally
covered with central ulceration. 7 cervical lymph nodes |
Calcitonin+,
CEA+, TTF-1+ (focal), Cytokeratin+, Chromogranin A+ |
157 pg/mL (ref. < 8) |
4 mm
focus of tumor with adjacent intravascular tumor |
|
Present
case 2015 |
01 |
51 years/F |
Hoarseness,
sore throat, otalgia and odynophagia |
Tip of
the epiglottis and 1 cervical lymph node |
Calcitonin+, CEA+,
TTF-1 negative, Cytokeratin+, Chromogranin
A+ |
(12 pg/ml, ref is < 8) |
Micro
PTC, MTC - |
MDNC:
moderately differentiated neuroendocrine carcinoma; CEA: carcinoembryonic
antigen; TTF: thyroid transcription factor; MTC: medullary throid
carcinoma; ACTH: adrenocorticitrophic hormone; NSE: neuron-specific
enolase; PTC: papillary thyroid carcinoma; MDNC:
moderately differentiated neuroendocrine carcinoma; CEA: carcinoembryonic
antigen; TTF: thyroid transcription factor; MTC: medullary throid
carcinoma; ACTH: adrenocorticitrophic hormone; NSE: neuron-specific
enolase; PTC: papillary thyroid carcinoma