Table 1: Literature review of documented giant cell angiofibromas in the head and neck with pathologic description.
|Authors||Head and Neck Site||No. Cases||Age Range||Gender Distribution||Histopathologic Features||Immunohistochemical Staining|
|Arifin, et al. ||Scalp||1||39||Female||Oval and round- to spindle-shaped cells intermixed with floret-like giant with
hypocellular areas. Giant cells lined the pseudovascular space. Presence of bony erosion.
|Positive: CD34 and Vimentin Negative: not mentioned|
|Shu, et al. ||Vocal cord||2||40-45||All Male||Patternless spindle cells with rich blood vessels and vascularity,
with presence of multinucleated cells lining pseudovascular spaces. Positive training: CD34,
Vimentin, CD99. Negative staining.
|Positive: CD34, vimentin, CD99 Negative: MSA, desmin, s100, aAT, aACT, CDC9, cytokeratin|
|Gonzalez-Perez, et al. ||Paraphyaryngeal Space||1||29||Female||Fibrous pseudocapsule of spindle cells, round to oval bland
nuclei and pseudoinclusions. Numerous floret like multinucleated giant cells,
angioectoid pseudovascular spaces.
|Positive: CD34, BCL2, CD99 Negative: smooth muscle actin, CKAE1/AE3, CK1/5/10/14,
s100, p63, CD31, EMA In-situ hybridization negative to SYT
gene (18q11.2) to rule out synovial sarcoma
|Rousseau, et al. ||Buccal Mucosa||1||61||Male||Presence of torturous, pseudovascular spaces, filled with floret type multinucleate
cells with large hyperchromatic nuclei.
|Positive: Vimentin, CD34 Negative: CD68, CD31, Factor VIII, Ulex europaeus lectin|
|De Andrade, et al. ||Buccal Mucosa||1||44||Male||Elongated, spindled, and wavy cells, intermingled with variable amounts
of blood vessels, pseudovascular spaces, and scarce multinucleated giant cells.
|Positive: Vimentin, CD34, bcl-2 (weakly) Negative: cytokeratin, smooth muscle
actin, s100, desmin, CD68, CD34
|Kintarak, et al. ||Buccal Mucosa||1||46||Female||Nonencapsulated, well circumscribed, with small spindle shaped proliferating
cells. Scattered multinucleated giant cells with peripherally arranged nuclei in
floret like pattern, lining pseudovascular spaces.
|Positive: CD34, factor XIIIa Negative: smooth muscle actin, desmin, s100|
|Mikami, et al. ||Submandibular Region||1||48||Female||Pseudovascular spaces lined by a discontinuous row of multinucleated
cells were seen against a background of spindle-shaped fibroblastic cell proliferation.
|Positive: CD34, Vimentin Negative: Factor VIII, desmin, smooth muscle actin,
myoglobin, s100, leuM1, lysozyme, alpha-1-antitrypsin, cytokeratin