Table 2: Comparison of the incidence and hazard ratio of coronary heart disease stratified by sex, age, and comorbidities between patients with and without CRS.

 

CRS (-)

CRS (+)

Variable

Event

PY

Rate#

Event

PY

Rate#

Crude HR

(95% CI)

Adjusted HR† (95% CI)

All

3337

370037

0.90

1173

93227

1.26

1.40 (1.31-1.49)***

1.30 (1.22-1.39)***

PTCA

9

 

0.02

4

 

0.04

1.77 (0.55-5.75)

1.53 (0.46-5.11)

Coronary angiography only without PTCA

552

 

0.15

165

 

0.18

1.19 (1.00-1.41)

1.08 (0.90-1.29)

Sex

 

 

 

 

 

 

 

Female

1573

190683

0.82

573

48066

1.19

1.45 (1.31-1.59)***

1.38 (1.25-1.52)***

Male

1764

179354

0.98

600

45162

1.33

1.35 (1.23-1.48)***

1.23 (1.12-1.35)***

Stratified age (years)

 

 

 

 

 

 

 

≤ 49

1213

276362

0.44

469

70249

0.67

1.52 (1.37-1.69)***

1.32 (1.19-1.48)***

50-65

1395

70390

1.98

472

17247

2.74

1.38 (1.24-1.53)***

1.24 (1.12-1.39)***

> 65

729

23285

3.13

232

5730

4.05

1.30 (1.12-1.50)***

1.21 (1.04-1.41)*

Comorbidity‡

 

 

 

 

 

 

 

 

No

1540

297312

0.52

396

63502

0.62

1.20 (1.08-1.34)**

1.34 (1.20-1.49)***

Yes

1797

72724

2.47

777

29725

2.61

1.07 (0.98-1.16)

1.17 (1.08-1.28)***

Rate#: incidence rate, per 100 person-years.

Adjusted HR†: Multivariable analysis including age, sex, and comorbidities such as diabetes mellitus, hypertension, hyperlipidemia, asthma, stroke, chronic obstructive pulmonary disease (COPD), alcohol-related illness, and tobacco dependency.

Comorbidity‡: Patients with any one of the comorbidities (diabetes mellitus, hypertension, hyperlipidemia, asthma, stroke, COPD, alcohol-related illness, and tobacco dependency) were classified into the comorbidity group.

*: P < 0.05, **: P < 0.01, ***: P < 0.001.

CRS: Chronic Rhinosinusitis; PY: Person-Years; HR: Hazard Ratio; CI: Confidence Interval; PTCA: Percutaneous Transluminal Coronary Angioplasty.